Tracheospasmolytic activity of vitetrifolin-E isolated from the leaves of Vitex trifolia L.
In searching of tracheospasmolytic active compounds from Vitex trifolia, we are now reporting isolation and identification of vitetrifolin-E from active fraction obtained from n-hexane extract of V. trifolia. Vitetrifolin-E blocked spontaneous contraction of male guinea pig trachea induced by histamine and was active in a model using sensitized guinea pig trachea stimulated by ovalbumin. Vitetrifolin-E inhibited tracheal contraction by 22.6% at dose of 1.3 x 10-4 M and by 86.1% at dose of 4.10-4 M. In a model using sensitized male guinea pig trachea, vitetrifolin-E also inhibited the contraction 83.5% (1.3 x 10-5 M).
Keywords: vitetrifolin-E, Vitex trifolia, tracheospasmolytic
Alam G, Wahyuono S, Ganjar IG, Hakim L, Timmerman H, and Verpoorte R., 2002, Tracheospasmolytic activity of viteosin-A and vitexicarpin isolated from Vitex trifolia. Planta Medica, 68: 1047-9
Ono M, Ito Y, and Nohara T., 2001, Four new halimane-type diterpenes, Vitetrifolins D-G, from the fruit of Vitex trifolia. Chem. Pharm. Bull. 49(9): 1220-2
Paudler, W. W., 1987, Nuclear Magnetic Resonance, general concepts and application, John Wiley & Sons, New York
Silverstein, R. M., and Webster, F. X., 1997, Spectrometric Identification of Organic Coumpounds, 6th edition, John Wiley & Sons, New York
Wahyuono S, Alam G, Gandjar IG, Hakim L, and Timmermann H., 2000, Antiasthmatic Indonesian Medicinal Plants: Their tracheospasmolytic activity induced by histamine. International Sendai Histamine Symposium "Histamine Research in the New Millenium" Sendai, Japan:November 22-25
- There are currently no refbacks.
Copyright (c) 2017 INDONESIAN JOURNAL OF PHARMACY
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Indonesian J Pharm indexed by:View My Stats