ANTIINFLAMMATORY EFFECTS OF Cinnamyl tiglate CONTAIN IN VOLATILE OIL OF KUNYIT (Curcuma domestica Val.)

Sri Isrina Oktavia Salasia, Rochmadiyanto ., Oktarina Fatimah

Abstract


The aim of this study was to evaluate the antiinflammatory effects of the cinnamyl tiglate contain in the volatile oil of kunyit (Curcuma domestica Val.) on the carrageenin induced inflammatory in Wistar albino rats (Rattus norvegicus). Cinnamyl tiglate was isolated using thin layer chromatography with the silica gel GF as stationary phase and the hexane with toluene as a mobile phase. Cinnamyl tiglate could be isolated using gas chromatography and mass spectrometry (GCMS). Inflammation of rats were induced by 1% carrageenin subplantar followed with oral administration of the cinnamyl tiglate at various doses of 1,1%, 4,4%, and 17,6%/kg bw. As controle were used rats treated orally with aspirin 450 mg/kg bw and volatile oil of kunyit 1,2 ml/kg bw. The volume of inflammations were measured with pletismograph. The analysis of GCMS showed that cinnamyl tiglate could be isolated from volatyle oil of kunyit in the second fraction with the concentration of 63,62%. Cinnamyl tiglate with dose of 1,1%/kg bw had no effects on the inflammatory reactions (P≥0,05). Cinnamyl tiglate with dose of 4,4%/kg bw could decrease the inflammatory reactions (P≤0,05) and with dose of 17,6%/kg bw the antiinflammatory effects were more significant (P≤0,01).

Key words: Cinnamyl tiglate, Curcuma domestica Val., antiinflammatory


Full Text:

Untitled

References


Anonim, 1988, Panduan Pelayanan Obat, Pembinaan dan Pengembangan Sumber Daya Manusia, PT. Kimia Farma, Jakarta.

Dahlan, R. 1999, Aktivitas Anti-inflamasi Ekstrak Daun Dewa (Gynura pseudochina D.C), Jurnal Sains dan Teknologi Farmasi, 4: 84-89.

Gill, B. D., 1978, Design and Analysis of Experiment in the Animals and Medical Sciences, 1st Ed., Iowa States University Press. Ames, 89-153.

Gritter, R. J., Bobbitt, J. M. and Schwarting, A. E., 1985, Introduction to Chromatography, Diterjemahkan oleh Kosasih Patmawinata. Terbitan Kedua, Penerbit ITB, Bandung.

Harborne, J. B., 1984, Phytochemical Methods, Diterjemahkan oleh Kosasih Padmawinata dan Iwang Soediro, Edisi 2, Penerbit ITB, Bandung, hal 127-131.

Mansjoer, S., 1997, Efek Anti Radang Mnyak Atsiri Temu Putih (Curcuma Zedoria Rosc.) Terhadap Udem Buatan Pada Tikus Putih Betina Galur Wistar. Majalah Farmasi Indonesia, 8: 35-41.

Mukhopadyay, A., Basu, N., Gathak, N. and Gujral, P.K., 1987, Antiinflammatory and irritant activity of curcumine analogues in rat. Agent and Action, 12: 508-515.

Rao, D. S., Sekhara, N. C. H., Satyarana, M. N. and Srinivasan, M., 1970, Effect of Curcumin in Serum and Liver Chlesterol Level in Rats, J. Nutr., 100: 1027-1039.

Shearn, M.A., 1989, Obat Anti Inflamasi Nonsteroid; Analgesik Nonopiat; Obat yang Digunakan pada Gout. Dalam : Katzung, B.G. Farmakologi Dasar dan Klinik. Edisi 3. Penerbit Buku Kedokteran EGC. hal. 474-479.

Solfain, R., Munarwan, Hayati, N., Agustina, S., Salasia, S.I.O., 2001, Khasiat Minyak Atsiri Kunyit (Curcuma domestica Val.) Sebagai Antiradang, J. Sain Vet., Vol. XIX No.1: 8-13.

Sudarsono, Pudjoarianto, A., Wahyono, S., Argo, D., Drajat, N. dan Wibowo, S., 1996, Obat Tradisional, Pusat Penelitian Obat Tradisional (PPOT), Universitas Gadjah Mada, Yogyakarta, hal. 55-59.

Supriyanto dan Supriyadi, 1991, Minyak Atsiri dan Rempah-rempah. Pusat Antar Universitas Pangan Dan Gizi, Universitas Gadjah Mada, Yogyakarta. hal. 77-85.

Ward, P. A., 1993, Inflamasi Dalam: Bellanti, J.A. Imunologi III diterjemahkan oleh Samik Wahab, Gadjah Mada University Press, Yogyakarta. hal. 71-86.

Wilmana, P. F., 1995, Analgesik Antipiretik Analgesik Anti Radang Non Steroid dan Obat Pirai. Farmakologi dan Terapi, Edisi IV, Bagian Farmakologi Fakultas Kedokteran, Universitas Indonesia, Penerbit Gaya Baru, Jakarta. hal. 207-222.




DOI: http://dx.doi.org/10.14499/indonesianjpharm0iss0pp162-168

Refbacks

  • There are currently no refbacks.




Copyright (c) 2017 INDONESIAN JOURNAL OF PHARMACY

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Indonesian J Pharm indexed by:

                                    
 
web
analytics View My Stats