A Preformulation of a Water Soluble Furosemide Dosage Form
Solid dispersion system of water-insoluble furosemide in polyvinylpirolidon (PVP) was prepared by a solvent method in various ratios of 1 : 1, 1 : 3, 1 : 5, 1 : 7 and 1 : 9 of the drug and PVP, respectively in order to improve furosemide solubility and dissolution. The improvement of furosemide solubility was studied by a solubility method in a shaking waterbath. The solubility test showed that various concentrations of PVP and temperature gave statistically significant increased of furosemida solubility (P < 0,05). The dissolution study of furosemide solid dispersion system was done using a dissolution tester at the rotation rate of 50 rpm. Furosemide concentration released was determined spectrophotometrically using a UV spectrofometer. This test showed a significant increased of furosemida solubility (P < 0,05), but with a prolonged of releasing time.
Key Word : solid dispersion, solubility, dissolution, bioavailability.
UI Press, Jakarta pp. 124 – 134
Chiou, W.L., and Riegelman, S., 1971, Pharmaceutical Application of Solid Dispersion System, J. Pharm. Sci., 60 (9), 1281-1301
Kelly, M.R., Cutler, R.E., Forrey, A.W., and Kimpel, B.M., 1974, Pharmacokinetics of Orally Administered Furosemide, Clin. Pharmacol. Ther., 15, 178-186
Pan, R. N., Chen, J. H., Chen, R. R. L., 2000, Enhancement of Dissolution and Bioavailability of Piroxicam in Solid Dispersion System, Drug-Dev. Ind. Pharm, 26(9), 989 - 994
Santoso, S., 2000, SPSS, Mengolah Data Statistika Secara Profesional, Gramedia, Jakarta, 371 – 380
Syukri, Y., Ben, E.S., Salman, 2000, Studi Sistem Dispersi Padat Furosemida – Urea, Eksakta, Univ. Islam Indonesia, Yogyakarta
Yalkowsky, S. H., 1981, Techniques of Solubilization of Drugs, Marcel Dekker, New York, 135 – 143.
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