MACARANGIN, A GERANYLATED FLAVONOID AND ANTICANCER ACTIVE COMPOUND ISOLATED FROM ETHYL ACETAT FRACTION OF Macaranga gigantifolia LEAVES
Macaranga known locally as mahang-mahangan has uniquely ecological function, and also became a part of traditional medicine in Indonesia. Macaranga genus also known as a sources of terpenoid and phenolic (flavonoid) compounds which have biological activity as antioxidant and anticancer (cytotoxicity).There are few phytochemical investigations have been done on M. gigantifolia species. As a part of our continuing research of isolation anticancer compound from natural product, a geranylated flavonoid compound (macarangin) has been isolated from ethyl acetate fraction of Macaranga gigantifolia leaves using chromatography methods. The isolated compund (isolat MG) was elucidated to gain the chemical structure based on spectroscopic data (LC-MS and FT-NMR). Cytotoxicity test of this compound was tested against MCF 7 cell lines, showed that macarangin has a potential activity with IC50 value 119.12μg/mL.
Key words: Macarangin, geranylated flavonoid, Macaranga gigantifolia, MCF 7 cell lines.
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Blattner, F.R., Weising, K., Banter, G., Maschwitz, U. and Fiala, B. 2001. Molecular Analysis of Phylogenetic Relationships among Myrmecophytic Macaranga Species (Euphorbiaceae). Molecular Phylogenetics and Evolution. 19(3):331-344.
Darmawan, A., Kosela, S., Kardono, L.B.S. and Syah, Y.M. 2012. Scopoletin, a coumarine derivative compound isolated from Macaranga gigantifolia Merr. Journal of Applied Pharmaceutical Science. 2(12):175-177.
Heyne, K. 1987. Tumbuhan Berguna Indonesia, Jilid I. Yayasan Sarana Wanajaya, Jakarta. 1163-1165.
Hnawia, E., Thoison, O., Voegelein, F.G., Bourret, D. and Sevenet, T. 1990. A Geranyl Substituted Flavonol from Macaranga vedeliana. Phytochemistry. 29:2367-2368.
Hui, W.H. and Ng, K.K. 1971. Isolation and Structure of Macarangonol, A Diterpene Ketol from Macaranga tanarius. Phytochemistry. 10:1617-1620.
Jang, D.S., Cuendet, M., Hawthorne, M.E., Kardono, L.B.S., Kawanishi, K., Fong, H.H.S., Mehta, R.G., Pezzuto, J.M. and Kinghorn, A.D. 2002. Prenylated Flavonoids of The Leaves of Macaranga conifera with Inhibitory Activity against Cyclooxygenase-2. Phytochemistry. 61:867-873.
Jin, S., Zhang, Q.Y., Kang, X.M., Wang, J.X. and Zhao, W.H. 2010. Daidzein induced MCF-7 breast cancer cell apoptosis via the mitochondrial pathway. Annals of Oncology. 21:263-268.
Phommart, S., Sutthivaiyakit, P., Chimnoi, N., Ruchirawat, S. and Sutthivaiyakit, S. 2005. Constituents of the Leaves of Macaranga tanarius. Journal of Natural Products. 6:927-930.
Schutz, B.A., Wright, A.D., Rali, T. and Sticher, O. 1995. Prenylated Flavanones from Leaves of Macaranga pleiostemona. Phytochemistry. 40:1273-1277.
Sutthivaiyakit, S., Unganont, S., Sutthivaiyakit, P. and Suksamrarn, A. 2002. Diterpenylated and Prenylated Flavonoids from Macaranga denticulata. Tetrahedron. 58:3619-3622.
Yoder, B.J., Cao, S., Norris, A., Miller, J.S., Ratovoson, F., Razafitsalama, J., Andriantsiferana, R., Rasamison, V.E. and Kingston, G.I. 2007. Antiproliferative Prenylated Stilbenes and Flavonoids from Macaranga alnifolia from the Madagascar Rainforest. Journal of Natural Products. 70:342-346.
Yunianto, P., Rosmalawati, S., Rachmawati, I., Suwarso, W.P. and Sumaryono, W. 2012. Isolation and Identification of Endophytoc Fungi from Srikaya Plants (Annona squamosa) Having Potential Secondary Metabolites as Anti-Breast Cancer Activity. Microbiology Indonesia. 6(1):23-29.
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