Sharma Mayank, Jain Dinesh Kumar


Chocolate  is  highly  sophisticated  and  infinitely  a  versatile food that can be combined to create completely different taste and texture  sensations.   The  objective  of  the  present  study  is  to develop  a  palatable  chocolate  formulation  of  Domperidone  and Cetirizine  for  pediatric  administration  and  to  increase  patient’s desire  to  consume  the  medication.  In  present  investigation chocolate  base  is  prepared  by  use  of  cocoa  powder,  coco  butter, lecithin,  and  pharmaceutical  grade  sugar.  Thereafter  drug  is incorporated  to prepared  chocolate base.  The medicated chocolate prepared  is  evaluated  for  appearance,  moisture  content determination using digital Karl Fischer titrator, blooming test, drug content  determination  &  drug  excipient  interaction  by  differential scanning calorimetry.

Key words: Medicated Chocolate, Pediatrics, Chocolate formulation

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Adamson GE., Lazarus SA., Mitchell AE., Prior RL., Cao G., et al., 1999. HPLC method for the quantification of procyanidins in cocoa and chocolate samples and correlation to total antioxidant capacity. J. Agric. Food Chem. 47, 4184– 4188.

Afoakwa, E., 2010. Chocolate science and technology, first ed. Wiley-Blackwell Publication, UK, pp. 217. Compact Oxford English Dictionary. http:// www. askoxford. com /dictionaries/? View=UK. Accessed April 9, 2007.

Fuhrman, B., Aviram, M., 2001. Flavonoids protect LDL from oxidation and attenuate atherosclerosis. Curr. Opin. Lipidol.12, 41–48.

Geleijnse, J. M. et al. 1999. Tea flavonoids may protect against atherosclerosis: the Rotterdam study. Arch. Intern. Med. 159, 2170– 2174.

Hammerstone, J. F., Lazarus, S. A., Schmitz, H. H., 2000. Procyanidin content and variation in some commonly consumed foods. J. Nutr.130, 2089–2092.

Hertog, M.G.L, Kromhout, D., Aravanis, et al. 1995. Flavonoid intake and long-term risk of coronary heart disease and cancer in the Seven Countries study. Arch. Intern. Med.155, 381–386.

Knight, I., 2000. Chocolate and cocoa: health and nutrition, first ed. Oxford: Blackwell Science Ltd.

Lang, K.W., 2007. Delivery of active agents using a chocolate vehicle. US Patent 0269558.

Lamuela-Raventos, R.M., Andres-Lacueva, C., 2001. More antioxidants in cocoa. J. Nutr.131, 834.

Lazarus, S.A., Hammerstone, J. F., 1999. Chocolate contains additional flavonoids not found in tea. Lancet 354,1825.

Llorens J., 2004. The physiology of taste and smell: how and why we sense flavors. Water. Sci. Technol. 49, 1-10.

Lawless H., 1985. Sensory development in children: research in taste and olfaction. J. Am. Diet Assoc. 85, 577-582.

Liem, D.G., Mennella J.A., 2002. Sweet and sour preferences during childhood: role of early experiences. Dev Psychobiol. 41, 388-395.

Mennella, J.A., Pepino, Y., Reed, D.R., 2005. Genetic and environmental determinants of bitter perception and sweet preferences. Pediatrics. 115, e216- e222.

Rodgers, G.C., 1994. The role of aversive bittering agents in the prevention of pediatric poisonings. Pediatrics. 93, 68-69.

Scalbert, A., Williamson, G., 2000. Dietary intake and bioavailability of polyphenols. J. Nutr.130, 2073– 2085.



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