CHOCOLATE FORMULATION AS DRUG DELIVERY SYSTEM FOR PEDIATRICS
Chocolate is highly sophisticated and infinitely a versatile food that can be combined to create completely different taste and texture sensations. The objective of the present study is to develop a palatable chocolate formulation of Domperidone and Cetirizine for pediatric administration and to increase patient’s desire to consume the medication. In present investigation chocolate base is prepared by use of cocoa powder, coco butter, lecithin, and pharmaceutical grade sugar. Thereafter drug is incorporated to prepared chocolate base. The medicated chocolate prepared is evaluated for appearance, moisture content determination using digital Karl Fischer titrator, blooming test, drug content determination & drug excipient interaction by differential scanning calorimetry.
Key words: Medicated Chocolate, Pediatrics, Chocolate formulation
Adamson GE., Lazarus SA., Mitchell AE., Prior RL., Cao G., et al., 1999. HPLC method for the quantification of procyanidins in cocoa and chocolate samples and correlation to total antioxidant capacity. J. Agric. Food Chem. 47, 4184– 4188.
Afoakwa, E., 2010. Chocolate science and technology, first ed. Wiley-Blackwell Publication, UK, pp. 217. Compact Oxford English Dictionary. http:// www. askoxford. com /dictionaries/? View=UK. Accessed April 9, 2007.
Fuhrman, B., Aviram, M., 2001. Flavonoids protect LDL from oxidation and attenuate atherosclerosis. Curr. Opin. Lipidol.12, 41–48.
Geleijnse, J. M. et al. 1999. Tea flavonoids may protect against atherosclerosis: the Rotterdam study. Arch. Intern. Med. 159, 2170– 2174.
Hammerstone, J. F., Lazarus, S. A., Schmitz, H. H., 2000. Procyanidin content and variation in some commonly consumed foods. J. Nutr.130, 2089–2092.
Hertog, M.G.L, Kromhout, D., Aravanis, et al. 1995. Flavonoid intake and long-term risk of coronary heart disease and cancer in the Seven Countries study. Arch. Intern. Med.155, 381–386.
Knight, I., 2000. Chocolate and cocoa: health and nutrition, first ed. Oxford: Blackwell Science Ltd.
Lang, K.W., 2007. Delivery of active agents using a chocolate vehicle. US Patent 0269558.
Lamuela-Raventos, R.M., Andres-Lacueva, C., 2001. More antioxidants in cocoa. J. Nutr.131, 834.
Lazarus, S.A., Hammerstone, J. F., 1999. Chocolate contains additional flavonoids not found in tea. Lancet 354,1825.
Llorens J., 2004. The physiology of taste and smell: how and why we sense flavors. Water. Sci. Technol. 49, 1-10.
Lawless H., 1985. Sensory development in children: research in taste and olfaction. J. Am. Diet Assoc. 85, 577-582.
Liem, D.G., Mennella J.A., 2002. Sweet and sour preferences during childhood: role of early experiences. Dev Psychobiol. 41, 388-395.
Mennella, J.A., Pepino, Y., Reed, D.R., 2005. Genetic and environmental determinants of bitter perception and sweet preferences. Pediatrics. 115, e216- e222.
Rodgers, G.C., 1994. The role of aversive bittering agents in the prevention of pediatric poisonings. Pediatrics. 93, 68-69.
Scalbert, A., Williamson, G., 2000. Dietary intake and bioavailability of polyphenols. J. Nutr.130, 2073– 2085.
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