PHYSICAL PROPERTIES OF WOUND HEALING GEL OF ETHANOLIC EXTRACT OF BINAHONG (Anredera cordifolia (Ten) Steenis) DURING STORAGE.
Binahong (Anredera cordifolia (Ten) Steenis) has been used as wound healing in traditional Indonesian medicine. The developing of the dosage forms using the formulation technology approach has been done. The aim of this study was to examine the physical properties of the wound healing gel of ethanolic extract of binahong during storage. The factorial design method 3 factors and 2 levels was employed to achieve this study. The three factors used in this study were Carbopol, CMC-Na and Caalginate with low and high level for each factor. The physical properties of the wound healing gel of ethanolic extract of binahong was evaluated on day 1, 30, 60 and 90 for viscosity and bioadhesion study. The result showed that CMC-Na and Caalginate increased the alteration of physical properties of wound healing gel of ethanolic extract of binahong during storage. The carbopol maintained the physical properties of the gel during storage.
Key words: bioadhesion, binahong, viscosity, wound healing gel.
Bochek AM., Yusupova LD., Zabivalova N.M. and Petropavlovskii GA. 2002. Rheological Properties of Aqueous HCarboxymethyl Cellulose Solutions with Various Additives. Rus. J. Appl. Chem., 75, 4–7.
Bouchard J., Abatzoglou, N., Chornet E. and Overend RP. 1989. Characterization of depolymerized cellulosic residues. Wood Sci. Technol.,23, 343–355.
Cockbill S., 2002, Wounds The Healing Process., Hospital Pharmacist, Vol 9, Oktober 2002, 255 – 260
Cornell MD., Kaiser NE., and Brenden RA., 1997, Wound Hydrating Gel with Novel Preservative System and Low Cytotoxicity, United States Patent, Patent number 5670169
Gushchin Na., Ostrovidova GU., and Sosnov E a., 2008. Antimicrobial polymeric composite films for medical use. Rus. J. Appl. Chem., 81, 132–135.
Kumar L., and Verma R., 2010. In vitro evaluation of topical gel prepared using natural polymer. Int. J. Drug Deliv., 2, 58–63.
Lim SW., Hong SP., Jeong SW., Kim B., Bak H., Ryoo HC., Lee SH. and Ahn SK. 2007. Simultaneous effect of ursolic acid and oleanolic acid on epidermal permeability barrier function and epidermal keratinocyte differentiation via peroxisome proliferator-activated receptor-alpha. J.Dermatol., 34, 625–34.
Lin H-Y., Kuo S-C., Chao P-DL., and Lin TD., 1988. A new sapogenin from boussingaultia gracilis. J. Nat. Prod., 5, 797–798.
Liu P., Peng J., Li J., and Wu J., 2005. Radiation crosslinking of CMC-Na at low dose and its application as substitute for hydrogel. Radiat. Phys. Chem., 72, 635–638.
Mallefet P., and Dweck, A.C., 2008, Mechanism of Wound Healing Examined, Personal Care, 75 – 83
Martens P., Metters AT., Anseth KS. and Bowman CN., 2001. A Generalized BulkDegradation Model for Hydrogel Networks Formed from Multivinyl Crosslinking Molecules. J.Phys. Chem., 105,
Meyvis TKL., De Smedt SC., Demeester J. and Hennink WE. 2000. Influence of the Degradation Mechanism of Hydrogels on Their Elastic and Swelling Properties during Degradation. Macromolecules., 33, 4717–4725.
Panouillé M. and Larreta-Garde V. 2009. Gelation behaviour of gelatin and alginate mixtures. Food Hydrocolloids., 23, 1074–1080.
Wittaya-areekul S., Prahsarn, C., and Sungthongjeen S. 2006. Development and in vitro evaluation of Chitosan-Eudragit RS 30D composite wound dressings. AAPS PharmSciTech.,7, E30.
Zhao Y., Hu F., Evans JJ. and Harris MT. 2011. Study of sol–gel transition in calcium alginate system by population balance model.Chem.Eng.Sci., 66, 848–858.
Zatz JL., and Kushla GP., 1996., Gels, in Lieberman HA., Rieger MM., and Banker GS., Pharmaceutical Dosage Forms: Disperse System Vol 2. ed 2, Marcell Dekker Inc., New York
- There are currently no refbacks.
Copyright (c) 2017 INDONESIAN JOURNAL OF PHARMACY
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Indonesian J Pharm indexed by:
View My Stats