POLYMERIC MICELLES: POTENTIAL DRUG DELIVERY DEVICES

Payal Deepak, Upendra Nagaich, Aman Sharma, Neha Gulati, Amit Chaudhary

Abstract


Polymeric micelles (PMs) have been the most popular and promising topic of many researches in the field of drug delivery and targeting for the past two decades. Polymeric micelles are the selfassembled nano-sized colloidal particles which are made up of amphiphilic block copolymers i.e. polymers consisting of hydrophobic block and hydrophilic block. In this highlight, we give an overview of the structure of micelles and polymeric micelles followed by a summary of the methods used for their preparation. We then focus on several kinds of PMs based on intermolecular forces such as polyion complex micelles (PICMs), non-covalently connected micelles (NCCMs) and recently developed smart polymeric assemblies which can respond to the application of external stimuli such as a change in temperature, pH, redox and light to afford novel nanomaterials. The types of polymers used in the preparation of PMs have also been highlighted so as to facilitate its use in drug delivery and targeting. These polymeric micelles nanocarriers have applications in drug delivery primarily such as anticancer therapy, to the brain to treat neurodegenerative diseases, antifungal agents, stimuli-responsive nanocarriers for drug and gene delivery, ocular drug delivery. Targeted drugs will hopefully reduce adverse reactions by limiting their action to cancer tissue only. Finally, this review broadly presents the basic aspects of PMs which help in delivery and targeting of actives with its recent advancements and applications.
Key words: micelles, polymeric micelles, block copolymer, stimuli sensitivity

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References


Adams ML., Lavasanifar A. Kwon GS. 2003. Minireview amphiphilic block copolymers for drug delivery. J. Pharm. Sci. 92: 1343−1355.

Aguilar MR., Elvira C., Gallardo A., Vázquez B., Román, JS. 2007. Smart polymers and their applications as biomaterials. Topics in Tissue Engineering. 3: 1-27.

Ai H., Flask C., Weinberg B., Shuai X., Pagel MD., Farrell D. et al., 2005. Magnetiteloaded polymeric micelles as ultrasensitive magnetic–resonance probes. Adv. Mater. 17: 1949-1952.

Akimoto J., Nakayama M., Sakai K., Okano T. 2009. Temperature-induced intracellular uptake of thermo responsive polymeric micelles. Biomacromolecules. 10: 1331-1336.

Alakhov V., Klinski E., Li S. 1999. Block copolymer-based formulation of doxorubicin from cell screen to clinical trials. Colloids Surf B: Biointerfaces. 16: 113-134.

Allen C., Maysinger D., Eisenberg A. 1999. Nano-engineering block copolymer aggregates for drug delivery. Colloids and Surfaces B: Biointerfaces. 16: 3-27.

Batrakova EV., Li S., Vinogradov SV., Alakhov VY., Miller, DW., Kabanov AV. 2001. Mechanism of pluronic effect on Pglycoprotein efflux system in blood brain barrier: contributions of energy depletion and membrane fluidization. J Pharmacol Exp Ther. 299: 483-493.

Batrakova EV., Miller DW., Li S., Alakhov VY., Kabanov AV., Elmquist WF. 2001. Pluronic P85 enhances the delivery of digoxin to the brain: in vitro and in vivo studies. J Pharmacol Exp Ther. 296: 551-557.

Couvreur P., Vauthier C. 2006. Nanotechnology: intelligent design to treat complex disease. Pharm Res. 23: 1417-1450.

Dhembre GN., Moon RS., Kshirsagar RV. 2011. A review on polymeric micellar nanocarriers. IJPBS. 2: 109-116.

Du J., Rachel K., Reilly O. 2009. Advances and challenges in smart and functional polymer vesicles. Soft Matter. 5: 3544–3561.

Garcia EG., Andrieux K., Gilb S., Couvreur, P. 2005. Colloidal carriers and blood–brain barrier (BBB) translocation: A way to deliver drugs to the brain. Int. J. Pharm. 298: 274–92.

Gil ES., Hudson SM. 2004. Stimuli-responsive polymers and their bioconjugates. Prog Polym Sci. 29: 1173-1222.

Guo M., Jian M. 2009. Non-covalently connected micelles (NCCMs): the origins and development of a new concept. Soft Matter. 5: 495–500.

Harada A., and Kataoka, K. 1997. Formation of stable and mono dispersive polyion complex micelles in aqueous medium from poly (L-lysine) and poly(ethylene glycol)-poly(aspartic acid) block copolymer. J. Macromol. Sci. Pure Appl. Chem. A. 34: 2119-2133.

Jeong JH., Byun Y., Park, TG. 2003. Synthesis and characterization of poly (L-lysine)-gpoly (D,L-lactic-co-glycolic acid) biodegradable micelles. J Biomater Sci Polymer Ed. 14: 1–11.

Jeong YI., Kim SH., Jung, TY. 2006. Polyion complex micelles composed of all-trans retinoic acid and poly (ethylene glycol)-grafted-chitosan. J Pharm Sci. 95: 2348-2360.

Jones MC., and Leroux JC. 1999. Polymeric micelles- a new generation of colloidal drug carriers. Eur J Pharm Biopharm. 48:101-111.

Kabanov AV., Batrakova EV., Melik-Nubarov, NS. 1992. New classes of drug carries: micelles of poly (oxyethylene) – poly (oxypropylene block copolymers as microcontainers for drug targeting form blood in brain. J Control Release. 22: 141-158.

Karine M., Robert G., Michael M. 2008. Colloidal drug delivery system-recent advances with polymeric micelles. Chimia. 62: 832-40.

Kataoka K., Kwon GS., Yokoyama M., Okano T., Sakurai Y. 1993. Block copolymer micelles as vehicles for drug delivery. J. Controlled Release. 24: 119–132.

Klaikherd A., Nagamani C., Thayumanavan S. 2009. Multi-stimuli sensitive amphiphilic block copolymer assemblies. J Am Chem Soc. 131: 4830-4838.

Kwon GS., and Kataoka K. 1995. Block copolymer micelles as long-circulating carriers for delivery of therapeutic and diagnostic agents. Adv Drug Deliv Rev. 16:295-299.

Lee VHL., Yamamoto A. 1990. Penetration and enzymatic barriers to peptide and protein absorption. Adv. Drug Deliv Rev.4: 171–177.

Licciardi M., Tang Y., Billingham NC., SP. 2005. Synthesis of novel folic acidfunctionalized biocompatible block copolymers by atom transfer radical polymerization for gene delivery and encapsulation of hydrophobic drugs. Biomacromolecules. 6: 1085–1096.

Li Y., Kwon GS. 1999. Micelle-like structures of poly (ethylene oxide)-block-poly(2-hydroxyethyl aspartamide)–methotrexate conjugates. Colloids Surf. B: Biointerfaces. 16: 217–226.

Liu GY., Chen CJ., Li DD., Wanzg SS., Ji J. 2012. Near-infrared light-sensitive micelles for enhanced intracellular drug delivery. J. Mater. Chem. 22: 16865-16871.

Liu S., Jones L., Gu FX. 2012. Nanomaterials for ocular drug delivery. Macromol Biosci. 12: 608-620.

Mall S., Buckton G., Rawlins DA. 1996. Dissolution behaviour of sulphonamides into sodium dodecyl sulphate micelles: A thermodynamic approach. J Pharm. Sci. 85: 75-78.

Matsumura Y., Hamaguchi T., Ura, T. 2004. Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelleencapsulated doxorubicin. Br J Cancer. 91: 1775-1781.

Matsumura Y. 2008. Poly (amino acid) micelle nanocarriers in preclinical and clinical studies. Adv Drug Del Rev. 60: 899-914.

Moghimi SM., Hunter AC., Murray JC. 2001. Long-Circulating and Target-Specific Nanoparticles: Theory to practice. Pharmacol. Rev. 53: 283-318.

Mourya, VK., Inamdar, N., Nawale, RB. And Kulthe, SS. 2011. Polymeric Micelles: General considerations and their Applications. Ind. J Pharm. Edu Res. 45:128-138.

Nishiyama N., and Kataoka K. 2006. Current state, achievements and future prospects of polymeric micelles as nanocarriers for drug and gene delivery. Pharmacol Ther. 112: 630-648.

Nostrum V. and Cornelus. 2012, Polymeric micelles for drug delivery. Sci Topics. Retrieved March 12, 2012, from http://www.scitopics.com/polymeric micelles for drug delivery.

Oerlemans C., Bult W., Bos M., Storm G., Nijsen JFW., Hennink WE. 2010. Polymeric micelles in anticancer therapy: targeting, imaging and triggered release. Pharm Res. 27: 2569–2589.

Otsuka H., Nagasaki Y., Kataoka K. 2003. PEGylated nanoparticles for biological and pharmaceutical applications. Adv Drug Del Rev. 55: 403-419.

Qiu LY., Bae YH. 2006. Polymer architecture and drug delivery. Pharm Res. 23: 1-30.

Ramesh C., Shri KN., Singh PN., Maiti P., Pandit JK. 2009. Review Polymeric nanoparticulate system: A potential approach for ocular drug delivery. J.Controlled Release. 136: 2–13.

Ranger M., Jones MC., Yessine MA., Leroux, JC. 2001. Well-defined diblock copolymers prepared by a versatile atom transfer radical polymerization method to supra molecular assemblies. J PolymSci Part A: PolymChem. 39: 3861-3874.

Ribeiro A., Sosnik A., Diego A., Veiga CF., Concheiro A., Lorenzo CA. 2012. Single and mixed poloxamine micelles as nanocarriers for solubilization and sustained release of ethoxzolamide for topical glaucoma therapy. J R Soc. Interface. 9: 2059–2069.

Rosler A., Vandermeulen GWM., Klok, HA. 2001. Advanced drug delivery devices via self-assembly of amphiphilic block copolymers. Adv.Drug Deliv. Rev. 53: 95–108.

Scholz C., Iijima M., Nagasaki Y., Kataoka K. 1998. Polymeric micelles as drug delivery systems: a reactive polymeric micelle carrying aldehyde groups. Polym. Adv. Tech. 9: 768-776.

Siegwart DJ., Oh JK., Matyjaszewski K. 2012. ATRP in the design of functional polymeric materials for biomedical application. Prog. Polym. Sci. 37: 18–37.

Sun HL., Guo BN., Li XQ., Cheng R., Meng FH., Liu HY. 2010. Shell-sheddable micelles based on dextran-ss-poly (Ɛcaprolactone) diblock copolymer for efficient intracellular release of doxorubicin. Biomacromolecules. 11: 848-854.

Torchilin VP. 2001. Structure and design of polymeric surfactant-based drug delivery systems. J. Controlled Release. 73: 137–172.

Trubetskoy VS. 1999. Polymeric micelles as carriers of diagnostic agents. Adv Drug Deliv Rev. 37: 81-88.

Torchilin VP. 2002. PEG-based micelles as carriers of contrast agents for different imaging modalities. Adv Drug Del Rev. 54:235-252.

Torchilin VP. 2007. Micellar Nanocarriers: Pharmaceutical Perspectives. Pharm Res. 24: 1-16.

Wang M., Zhang G., Chen D., Jiang M., Liu S. 2001. Noncovalently connected polymeric micelles based on a homopolymer pair in solutions. Macromolecules. 34: 7172-7178.

Wang YC., Tang LY., Sun TM., Li CH., Xiong MH., Wang J. 2008. Self-assembled micelles of biodegradable triblock copolymers based on poly (ethyl ethylene phosphate) and poly (ε-caprolactone) as drug carriers. Biomacromolecules. 9: 388-395.

Xiaohui P., Jie L., Yun G., Xingxing Y., Hao Y., Qi Y. 2012. Study progression in polymeric micelles for the targeting delivery of poorly soluble anticancer agents to tumor. Asian J Pharm Sci. 7: 1-17.

Yagui COR., Junior AP., Tavares LC. 2005. Micellar solubilization of drugs. J Pharm Pharmaceut. Sci. 8: 147-163.

Yokoyama M., Miyauchi, M., Yamada N., Okano T., Sakurai Y., Kataoka K. et al., 1990. Characterization and anticancer activity of the micelle forming polymeric anticancer drug adriamycin-conjugated poly(ethylene glycol)-(aspartic acid) block copolymer. Cancer Res. 50: 1693–1700.

Yokoyama M., Okano T., Sakurai Y., Suwa S. And Kataoka, K. 1996. Introduction of cisplatin into polymeric micelles. J Control Release. 39: 351-356.

Yokoyama M. 2011. Clinical applications of polymeric micelle carrier systems in chemotherapy and image diagnosis of solid tumors. J. Exp. Med. 1-8.

Zhanga J., Lia S., Li X. 2009. Polymeric nanoassemblies as emerging delivery carriers for therapeutic applications: A review of recent patents. Recent Pat Nanotechnol. 23:225-231.

Zhang JX., and Ma PX. 2009. Polymeric coreshell assemblies mediated by host-guest interactions: Versatile nanocarriers for drug delivery. Angew Chem Int Ed. 48: 964-968.

Zhang X., Zhuo R., Yang Y. 2002. Using mixed solvent to synthesize temperature sensitive poly (N-isopropylacrylamide) gel with rapid dynamic properties. Biomaterials. 23: 1313-1318.

Zhang Y., and Jiang M. 2006. New approaches to stimuli responsive polymeric micelles and hollow spheres. Front Chem. 1: 364- 368.




DOI: http://dx.doi.org/10.14499/indonesianjpharm0iss0pp222-237

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