COMPRESSIONAL CHARACTERISTICS OF Piper Guineense FRUIT

Bakre Lateef Gbenga; Ayodele Damilola

doi:10.14499/indonesianjpharm0iss0pp186-192

COMPRESSIONAL CHARACTERISTICS OF Piper Guineense FRUIT

Bakre Lateef Gbenga, Ayodele Damilola

Abstract

The dried fruit of Piper guineense is widely used for its antibacterial and antifungal properties. The objective of this present study was to examine the compressibility of dried powdered fruits of Piper guineense with a view to determining the suitability of its formulation into tablet dosage form. The compressional properties was studied in comparison with that of microcrystalline cellulose, dicalcium phosphate dihydrate and corn starch BP using density measurements and the Heckel and Kawakita equations for the analysis of the compression data at dwell times 5, 15 and 30s. The Heckel plots showed that the P. guineense powder is a Type A material and the degree of onset of plastic deformation increases as the dwell time is increased. Piper guineense exhibited the fastest onset of plastic deformation at 30s dwell time and the overall amount of plastic deformation was higher for Piper guineense than cornstarch and dicalcium phosphate dihydrate at all dwell times. The overall amount of plastic deformation for Piper guineense was highest at 15s dwell time. Results suggest that it should be of significant benefit to use a dwell time of 15s for the compression of Piper guineense powder.
Key words: Piper guineense, cornstarch, microcrystalline cellulose, dwell time, compressional characteristics

Full Text:

Untitled

References

Celik, M., 1992, Overview of compaction data analysis techniques, Drug Dev. Ind. Pharm., 18, 767-810.

Deodhar, U. P., Paradkar, A. R., Purohit, A. P., 1998, Preliminary evaluation of Leucaena leucocephala seed gum as a tablet binder, Drug Dev. Ind. Pharm., 24, 577-582

Humbert – Droz, P., Gurny R., Mordier, D., 1983, Densification behaviour of drugs presenting availability problems. Int. J. Pharm. Tech. Manuf. 4, 29-35

Itiola, O. A., Pilpel, N., 1986a, Tableting characteristics of metronidazole formulations, Int. J. Pharm., 31, 99 – 105

Jivraj, M., Martini, L. G., Thomson, C. M., 2000, An overview of the different excipients useful for the direct compression of tablets, PSTT, 3, 58-63

Kawakita, K., Ludde, K. H, 1970/71, Some considerations on powder compression equations Powder Technol., 4, 61-68

Kumar, V., Kothari, S. H., 2006, Effect of compressional force on the crystallinity of directly compressible cellulose excipients. Int. J. Pharm., 177, 173-182

Leuenberger, H., Rohera, B. D., 1986, Fundamentals of powder compression.-The compactibility and compressibility of pharmaceutical Powders, Pharm. Research, 3, 12-21

Lin C., Cham, T., 1995, Compression behaviour and tensile strength of heat treated polyethyleneglycols, Int. J Pharm., 118, 169-179

Mangathayaru, K., Umashankar, G., Murlitharan, G., Cordairayen, E., Vasantha, J., 2004, Indian Journal of Pharmaceutical Sciences, January-February : 123-125

Niwa, T., Takeuchi, H., Hino, T., Itoh, A., Kawashima, Y., Kiuchi, K., 1994, Preparation of agglomerated crystals for direct tabletting and microencapsulation by the spherical crystallization technique with a continuous system, Pharm. Research, 11, 478-484

Patel, S., Kaushal, A., Bansal, A., 2006, Effect of particle size and compression force on compaction behaviour and derived mathematical parameters of compressibility. Pharm Res. Pharmacol., 28, 5–8

Heckel, R.W., 1961a, Density–Pressure Relationship in Powder Compaction, Trans Metall. AIME, 4, 4671–675

Scott, I. M., Jensen, H.R., Sims S., Arnason J. T., Philogene B., 2004, Efficacy of Piper (Piperaceae) extracts for control of common home and garden insect pests. Journal of Economic Entomology, 97, 1390-1403.

Shivinand, P., Sprockel, O. I., 1992, Compaction behaviour of cellulose polymers, Powder Technol., 67, 177-184

DOI: http://dx.doi.org/10.14499/indonesianjpharm0iss0pp186-192