Sunil Thakral, Gagan Deep Singh, Neetu Kansal, Amarjit Singh


Gastroretentive dosage forms extend significantly the period of time over which the drug may be released. This prolonged gastric retention improves bioavailability, decrease drug waste and improve solubility of drugs that are less soluble in a high pH environment due to their availability in gastric pH for longer duration of time.Floating drug delivery systems have a bulk density less than gastric fluids and hence remain buoyant in the stomach. The main objective of the present study was to develop Gastroretentive (GR) controlled release ormulations of Metoprolol to prolong the gastric retention time so that its bioavailability can be improved. The formulations were prepared by using swellable polymers like HPMC K4M, HPMC K15M, HPMC K100M, Guar Gum, Xanthan Gum, Sodium carboxymethyl cellulose and various effervescent compounds, e.g. sodium bicarbonate, and citric acid by the direct compression method. All the formulations were evaluated for different parameters like floating lag time, total floating time, hardness, weight variation, density measurements, drug content and water uptake/swelling index. Dissolution studies were done for all formulations in 0.1N HCl (pH 1.2). Formulations F3, F4 and F10 were found to provide maximum sustained release of metoprolol s uccinate up to 24 h with optimum floating properties.
Key words : Controlled release; Gastro retentive; HPMC; Guargum; Xantham gum

Full Text:



Gupta, SK., Gupta, U., Omray, LK., Yadav, R. and Soni, VK., 2010. Preaparation and characterization of floating drug delivery system of acyclovir. Int. J. App. Pharm. 2(3), 7-10.

Hoffman, A., 1998. Pharmacodynamic aspects of sustained release preparations. Adv. Drug Del. Rev. 33(3), 185-189.

Klausner, EA., Lavy, E., Friedman, M. and Hoffman, A., 2003. Expandable gastroretentivedosagge forms. J. Controll Release. 90(143-162.

Longer, MA., Ch'Ng, HS. and Robinson, JR., 1985.Bioadhesive polymers as platforms for oral controlled delivery iii : Oral delivery of chlorthiazide using abioadhesive polymer. J. Pharm. Sci. 74, 406-411.

Mojaverian, P., Fergusan, RK., Vlasser, PH., Rocu, ML., Oren, A., Fix, JA., Caldwell, LJ. and Gardner, C., 1998. Effect of gender, posture and age on gastric residence time of an indigestible solid: Pharmaceutical consideration. Pharm. Res. 5(10), 639-644.

Patil, JM., Hirelakar, RS., Gide, PS. and Kadam,VJ., 2006.Trends in floatin drug delivery systems. J.Sci. & Indus Res. 65(11-21.

Sharma, N., Agarwal, D., Gupta, MK. and Khinchi, MP., 2011. A comprehensive review on floating drug delivery system.Int. Res. Pharm. and Biomed. Sci. 2(2), 424-441.

Sheth, NS. and Mistry, RB., 2011.Formulation and evaluation of floating drug delivery system. Int. J. Pharma and Bio Sci. 2(1), P 571-P 580

Singh, BN. and Kim, KH., 2000. Floating drug delivery system: An approach to oral controlled drug delivery via gastric retention. J. Control. Rel. 63(235-259.

Timmermans, J. and Moes, AJ., 1994. Factors controlling the buoyancy and gastric retention capabilities of floatinng matrix capsules: New data for reconsidering the controversy. J. Pharm Sci. 83(1), 18-24.



  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Indonesian J Pharm indexed by:

analytics View My Stats