Rana Zainuddin, Alpana Kulkarni, Hemant Chavan, Gunjan Patil, Zahid Zaheer, Jaiprakash N. Sangshetti


Taste mainly depends on the physiology, sensitivity and structure of taste buds. It is an important parameter in administering drugs orally. Bitter taste is a major limitation to patient compliance. Donepezil hydrochloride (DH) is a bitter drug used in Alzheimer's disease. Amongst the many techniques for taste masking, using ion exchange resins has been extensively reported. The technique of forming tasteless complexes with bitter drugs involves selection of most appropriate exchanger and optimization of complexing ratio. The aim of the present work was to select the best cationic exchanger amongst Indion 414, Indion 234 and Indion 214. All parameters were optimized to produce drug-loaded tasteless complexes. Complexation was carried out using batch process prior to which, acid-alkali activation was performed to remove adsorbed impurities from the resin bed surface and hence improve loading efficiency. UV-spectrophotometric method was used to determine percent drug loading. The molecular properties of drug resin complexes were studied using Fourier Transform Infra-red Spectroscopy, Differential Scanning Calorimetry and Xray Powder Diffraction which confirmed complexation. Indion 414 was found to give highest drug loading and minimal drug was released from the complex at salivary pH.

Key words: Donepezil HCl, Ion exchange resins, Molecular properties, Taste masking

Full Text:

PDF (107-115)


Abhijeet YP., Bhoyar PK., Baheti JR., and Kardel SM. 2012. Formulation and evaluation of stable oral formulation of bitterless ofloxacin complexed with ion exchange resin, World J of Pharm. and Pharm. Sci., 1(1), 384392.

Amr H., Sherien K., Ahmed K., and Ahmed A. 2011. Preparation, Characterization, and In-vitro/vivo Evaluation of Indion-based Chewable Tablets of Paracetamol and Ibuprofen for Pediatric Use, J of Am. Sci., 7(12),831-844.

Bhagwatwar HP., Bhushan I., Devarakonda SN., Dudipala S., Kharwade P., Kikkuru SR., Komareddy RK., Lilakar JD., Mohammed AB., Patil AV., Snehalatha M., Sreedharala VN.,

Tummala AK., and Vishwanathan NB. 2010. EP2146693A2.

Bhoyar PK. and Amgaonkar YM. 2011. Taste masking and molecular properties of Metformin Hydrochloride-Indion 234 complexes, J Young Pharmacists, 3(2), 112118.

Chandewar AV., Kshirsagar MD., and Pande S. 2011. Ion exchange resins Pharmaceutical applications and recent advancements, Int J of Advances in Pharm Sci., 2, 8-16.

Dahima R. and Sharma R. 2010. Comparative study of Ion-exchange resin Indion 204 and Indion 214 for the taste masking of Metoclopramide Hydrochloride and formulation of rapid-disintegrating

tablets, Asian J Pharm., 4(2), 110-115.

Douroumis D. 2011. Orally disinterating dosage forms and taste-masking technologies, Expert Opin Drug Deliv., 8(5), 665-675.

Pilgaonkar PS., Rustomjee, MT., and Gandhi, A.S., US Patent No. 2010/0215740 A1.

Salve PS., 2011, Development of sustained release beads for salbutamol sulphate using ion exchange resin, Asian J. Pharm. Tech., 1 (4),104-118.

Shalini S. and Shaila L., 2010, Taste Masking Technologies: A Review, Int J Pharm Pharm Sci., 2(2), 6-13.

Yan YD., Woo JS., Kang JH., Yong CS., et al., 2010, Preparation and evaluation of taste-masked Donepezil hydrochloride orally disintegrating tablets, Biol Pharm Bull., 33(8),1364-70.

DOI: http://dx.doi.org/10.14499/indonesianjpharm24iss2pp107-115


  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Indonesian J Pharm indexed by:


analytics View My Stats