Evaluation of drug release from fatty based suppository: the difference between intrinsic and non-intrinsic dissolution methods
The results showed that the drug release using non-intrinsic dissolution method was always higher than that of the intrinsic method at any drug concentration, the drug concentration has not showed proportional relationship with their release although the drug release tend to be higher as the concentration was higher.
Key words: suppository, dissolution
Ansel, H.C., Popovich, N.G. and Allen, L.V., 1995, Pharmaceutical Dosage Forms and Drug Delivery System, Williams & Wilkins, Baltimore, p.424-442
Blaey, C.F. and Tukker, F.F., 1990, Suppositories and Pessaries, in : Aulton, M.E., 1990, Pharmaceutics, the Science of Dosage Forms Design, ELBS, Hongkong, p.412-421
Carb, G.B., 1980, Disponibilite a partir des formes pharmaceutique solides destinees a la voie rectale : application a la capsule molle rectale, Internat. Cong. Pharm. Techn., Paris
Denoel, 1971, Pharmacie Galenique, Tome V, Press Univ. Liege, Liege
Fudholi, A., 1982, Kontrol Kecepatan Pelarutan In-vtro, Permasalahan dan Alat, Medika, 8, p. 570-574
Higuchi, T., 1960, Physical Chemical Analysis of Percutaneous Absorption Process from Crema and Ointment, J. Soc. Cosm. Chem., 11, p. 85-97
Higuchi, T., 1961, Rate of Release of Medicament from Ointment Base Containing Drug in Suspension, J. Pharm. Sci., 50, p. 874-875
Khan, K.A., 1975, The Concept of Dissolution Efficiency, J. Pharm. Pharmacol., 27, p. 48-49
Kislalioglu, S., 1980, In-vitro Release Properties of Caffeine I; Effect of Drug Concentration, Internat. Cong. Pharm. Techn., Paris
Liebe, D.C., 1996, Packaging in Pharmaceutical Dosage Forms, in: Banker, G.S. and Rhodes, C.T., 1996, Modern Pharmaceutics, 3rd ed. and expanded, Marcel Dekker Inc., New York, p. 716-717
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