Evaluation of antibiotic usage in patient with fever in a private hospital in Yogyakarta (period January – June 2002)

Aris Widayati, L. Endang Budiarti, Imono Argo Donatus

Abstract


Fever as a symptom may indicate to any other diseases. According to the standard therapy by IDI (1998) fever should be treated without antibiotic, but the fact showed that 70 % antibiotics were used for treatment. This study aimed at describing about fever and evaluating antibiotic usage in patients with fever as a final diagnose by appropriateness, effectiveness, and safety as a criteria of evaluation.
The present study was done with retrospective data collection and descriptive-evaluative design. Data was collected from medical records within a period from 2002 January to June. A number of 157 patients were used for the assesment.
The highest percentage of patient’s fever was a group of 17 – 60 years old (63. 28%). The final diagnose was fever (29.58%) and others (70.42%) such as viral infection (17.16%), DHF (8.28%), DF (7.01%) and acute respiratory traction infection (5.92%). There were 29 kinds of antibiotics (79.62%) that given to the patients as an empirical therapy and the highest was pefloxacin (13.14%). The percentage of antibiotic usage in patients with fever as a final diagnose (50 patients) was 86.00% (21 kinds of antibiotics) and the highest was pefloxacin (17.19%). Both of fever less than 5 days or
more than 5 days were treated with antibiotic, which was inappropriate usage because fever less than 5 days related to viral infection. There was only 4.65% had a culture and sensitivity test, which was appropriate antibiotics usage. There were 46.51% no growth of culture and 48.84% without culture, which was inappropriate antibiotics usage. Treatment with and without antibiotics could normalize vital signs each was 90.70% and 85.71% with no significant difference (with non parametric exact probability Fisher analysis, CI 0.05) and RR value (95%, 0.69-1.30). Patient’s recoveries were 88.37% and 85.71% with and without antibiotic therapy with no significant difference (CI 95% and 0.96 RR value with CI 95%; 0.66 – 1.41). There were two cases (4.00%) of contraindication and 12.00% of potential drug interactions. According to the standard therapy and supporting data of this study, so that fever should not always be treated with antibiotic.
Key words: antibiotic, fever, evaluation.

Full Text:

Untitled

References


Anderson, O.P., Knoben, J.E., Troutman. G.W., 2002, Handbook of Clinical Drug Data, 10 th Edition, p.166, Mc.Graw Hill, New York.

Ernst, J.E., 2000, Infectious Disease: Introduction, in Herfindal, T.E., Gourley, R.D., (eds): Textbook of Therapeutics Drug and Disease Management, 7th Ed., p.1357, Lippicontt Williams & Wilkins, Phialdelpia.

IDI, 1998, Standar Pelayanan Medis, Departemen Kesehatan RI.

Jacobs, A.R., 2002, General Problems in Infectious Disease, in Tierney, M.L., McPhee, J.S., Papadakis, A.M (eds.): Current Medical Diagnosis & Treatment, 41st Ed., p.1295, The McGraw-Hill, New York.

Schroeder,S.A., Pignone,M., McPhee, J.S., 2002, General Approach to the patient; Health maintenance & Disease Prevention; & Common Symptoms, in Tierney, M.L., McPhee, J.S., Papadakis, A.M., (eds): Current Medical Diagnosis & Treatment, 41st Ed., p.27, The McGraw-Hill, New York.

Strand, M.L., Cipolle, J.R., Morley, C.P., 1998, Pharmaceutical Care Practice, p.14,26,75,78,132., McGraw-Hill, New York.




DOI: http://dx.doi.org/10.14499/indonesianjpharm0iss0pp144-150

Refbacks

  • There are currently no refbacks.




Copyright (c) 2017 INDONESIAN JOURNAL OF PHARMACY

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Indonesian J Pharm indexed by:

                                    
 
web
analytics View My Stats