EVALUATION OF ANTIMICROBIAL POTENTIALS OF Cardiospermum halicacabum Linn.
Antimicrobial activity of Cardiospermum halicacabum shoot extracts were studied on gram-positive bacteria such as Staphylococcus aureus, Bacillus substilis, and gram-negative bacteria such as E.coli, Proteus vulgaris, and fungus Candida albicans. Disc diffusion method was used to study the antimicrobial activity of aqueous, ethanol, chloroform and ether extracts of C. halicacabum. Ampicillin was used as reference standard at 10 mg/disc concentration. Extracts of C. halicacabum exhibited a significant antibacterial activity except the aqueous extract. Ethanolic extract was found to be very effective with maximum activity index (0.84). The ethanolic extract exhibited minimum inhibitory concentration (MIC of 0.25 mg/mL against Staphylococcus aureus, Bacillus substilis, E. coli and Proteus vulgaris and 0.125 mg/mL against Candida albicans. The MIC of chloroform and ether extracts ranged between 0.25 and 1.0 mg/ml against the test organisms. All the extracts showed antifungal activity against Candida albicans.
Key words: antimicrobial activity, Cardiospermum halicacabum shoot system, solvent extraction,.
Ali AM., El-Sharkawy’ SH., Hamid' JA., Ismail NH, and Lajis' NH., 1995, Antimicrobial activity of selected Malaysian plants. Pertanika J. Trop. Agri. Sci., 18 (1), 57-61. Asha VV. and Pushpangadan P., 1999, Antipyretic activity of Cardiospermum halicacabum, Indian J. Exp. Biol., 37 (4), 411-414.
Bauer AW., Kirby WMM., Sherris JC. and Turek M., 1966, Antibiotic Susceptibility Testing by a Standardized Single Disc Method, Amer. J. Clin. Pathol., 45, 493496.
Dhar ML. and Dhawan BN., 1998, Indian J. Exp. Biol., 232, 6-9. Kelmanson JE., 2000, Zulu Medicinal Plants with Antibacterial Activity, Journal of Pharmacology, 69, 241-246.
Nadkarni AK., 1996, Indian Materia Medica, Volume 1: Popular Prakashan, Mumbai, pp. 271.
Sasidharan VK., Krishnakumar T., Manjula CB., 1998, Antimicrobial activity of Nine
common plants in Kerala, India.
Philippine J. Sci., 127, 65-71. Shakhtmeister IY. and Sharipova IV., 1997, Treatment of chronic dermatoses with plant pharmaceuticals. Vestnik Dermatologii i Venerologii, 6, 33-35.
I.M. Sechenov Mosc. Med. Acad., Moscow, Russia Srinivas K., Choudary KA., 1998, Phytochemical examination of Cardiospermum halicacabum Linn. Indian J. Nat Prod, 14 (1), 26-27.
Warrier PK., 1996, Indian Medicinal Plants, Volume 1., Orient Longman Ltd., Chennnai, pp. 377-379.
- There are currently no refbacks.
Copyright (c) 2017 INDONESIAN JOURNAL OF PHARMACY
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Indonesian J Pharm indexed by:View My Stats