FORMULATION AND EVALUATION OF MUCOADHESIVE BUCCAL TABLET OF DOMPERIDONE MALEATE

Yuwaraj Dilipsingh Dixit, Pravin Babarao Suruse, Umesh Dhaniram Shivhare

Abstract


The objective of the present study was to develop and evaluate mucoadhesive dosage form of Domperidone maleate. It is an antiemetic synthetic benzimidazole compound that acts as a dopamine D2 receptor antagonist. Mucoadhesive Domperidone maleate tablet formulation was prepared by direct compression method. The formulation F3 containing (Carbopol 940 + sodium alginate) was found to be best among all the formulation batches because of its consistent release rate for 7 h and extent of drug release was 94.44%. Graphical treatment of the formulation F3 to Higuchi’s equation showed that the drug release was diffusion mediated. In-vitro permeability study for formulation F3 for 7 h had shown 76.69% drug release. FTIR studies showed no evidence on interaction between drug and polymers.

Key words: Domperidone maleate, Mucoadhesive tablet, antiemetic


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References


Bayrak Z., Tas C., Tasdemir U., Erol H., Ozkan CK., Savaser A., Ozkan, Y., 2011, Formulation of Zolmitriptan sublingual tablets prepared by direct compression with different polymers: In-vitro and Invivo evaluation. Eur. J. Pharm. Biopharm., 78(3), 499-505.

EL-samaligy, M. S., Yahia, S. A., Basalious, E. B., 2010, Evaluation of Mucoadhesive Hydrogels loaded with Diclofenac sodium-chitosan microspheres for rectal administration. AAPS PharmSciTech., 11(4), 1695-1702.

Emami, J., Varshosaz, J., Saljoughian, N., 2008, Development and evaluation of controlled-release mucoadhesive Verapamil hydrochloride tablets. DARU. 16, 62-69.

Gavaskar B., Venkateswarlu E., Kumaraswamy, D., Dooda D., and Nagaraju M., 2010, Formulation and Evaluation of Mucoadhesive Tablets of Baclofen. Int. J. Pharm. Tech., 2(2), 396-409.

Hillery AM., Llyod AW., Swarbrick J., 2001, Drug Delivery and Targeting for Pharmacists and Pharmaceutical Scientists, London: Taylor and Francis, pp. 475.

Indian Pharmacopoeia, 2007, Vol 1: Ministry of Health and Family Welfare, Govt. of India, Indian Pharmacopoeia Commission, Ghaziabad, pp.149.

Indian Pharmacopoeia, 2007, Vol 2: Ministry of Health and Family Welfare, Govt. of India, Indian Pharmacopoeia Commission, Ghaziabad, pp.1050.

Javier OM., and McConville JT., 2011, Manufacture and characterization of mucoadhesive buccal films. Eur. J. Pharm. Biopharm., 77, 187-199.

Juq, M., Becirevic-Lacan, M., 2004, Influence of hydroxypropyl-b-Cyclodextrin complexation on Piroxicam release from mucoadhesive tablets. Eur. J. Pharm. Sci., 21(2-3), 251-260.

Kasshapa G., Desai H., and Pramod Kumar TM., 2004, Preparation and evaluation of a novel buccal adhesive system. AAPS PharmSciTech., 35, 1-9.

Martindale, W., Sweetman, S. C., 2002, Martindale: The Complete Drug Reference, London: Pharmaceutical Press, pp. 12241225.

Menon SS., Basavaraj BV., Bharath S., Deveswaran R., and Madhavan V., 2011, Formulation and evaluation of Ibuprofen tablets using orange peelpectin as binding agent. Der. Pharmacia. Lettre., 3(4), 241-247.

Miyazaki S., Nakayama A., Oda M., Takada M., and Attwood D., 1995, Drug release from oral mucosal adhesive tablets of chitosan and sodium alginate. Int. J. Pharm., 118, 257-263.

Nakhat PD., Kondawar AA., Rathi LG., 2008, Development and In-vitro evaluation of buccoadhesive tablets of Metoprolol tartrate. Ind. J. Pharm. Sci., 70 (1), 121124.

Rodriguez C R., Bruneau N., Barra J., Alfanso D., and Doelker E., 2000, Hydrophilic Cellulose Derivatives as Drug Delivery Carriers: Influence of Substitution Type on the Properties of Compressed Matrix. In: Donald L. Wise, Handbook of Pharmaceutical Controlled Release Technology, Marcel Dekker, Inc., New York, Basel, pp. 1-35.

Singh B., Chakkal SK., Ahuja N., 2006, Formulation and optimization of controlled release muccoadhesive tablets of Atenolol using Response surface methodology. AAPS PharmSciTech., 7(1), E19-E28.

Tewes F., Boury F., and Benoit J., 2006, Biodegradable Microspheres: Advances in Production Technology. In: Benita Simon, Microencapsulation Methods and Industrial Applications, Volume 158: CRC Press. New York, London, pp. 42-43.

Yamsani VV., Gannu R., Kolli C., Rao ME., and Yamsani MR., 2007, Development and in-vitro evaluation of mucoadhesive Carvedilol tablets. Acta. Pharm., 57(2), 185-197.




DOI: http://dx.doi.org/10.14499/indonesianjpharm24iss1pp47-55

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