DESIGN, DEVELOPMENT AND IN VITRO EVALUATION OF CAFFEINE LOADED NATURAL GUM MATRIX TABLET
The present research work was carried out to develop sustained release tablets of caffeine using natural matrix former (tragacanth) and different filling polymers like hydroxyl propyl methyl cellulose (HPMC K15M) and ethyl cellulose (EC). Caffeine was used as model drug. The polymers and tragacanth gum were incorporated in varying ratios into a matrix system using wet granulation technique. All the lubricated formulations were compressed into tablets and evaluated for various physicochemical properties such as thickness, hardness, friability, weight variation, drug content and in vitro drug release studies. From the investigation it was observed that increase in the amount of gum tragacanth (from F1 to F5) led to reduced friability, increased hardness and retarded drug release. Different filling polymers also sustained the drug release. The in vitro drug release data were tted in various release kinetics models to understand th mechanism of drug release. All solid matrix formulations were found to follow Higuchi kinetics, indicating the diffusional release of drug from the matrix type system. The Formulation F5 containing highest amount of gum tragacanth have shown promising results. The findings of the current investigation clearly indicate the potential of tragacanth gum to be used as release retardant and natural matrix material in sustained release formulations.
Key words: Sustained release, Matrix tablets, Tragacanth, Caffeine.
Arora G., Malik K., Singh I., Arora S. and Rana V., 2011, Formulation and evaluation of controlled release matrix mucoadhesive tablets of domperidone using Salvia plebeian gum, J Adv Pharm Tech Res, 2(3), 163-9.
Baloglu E., 2010, A Design and Evaluation of Layered Matrix Tablet Formulations of Metoprolol Tartrate, AAPS Pharm Sci Tech, 11(2), 563-573.
Dash S., Murthy PN., Nath L. and Chowdhury P., 2010, Kinetic modeling on drug release from controlled drug delivery systems, Acta Pol Pharm, 67 (3), 217-223. Higuchi T., 1963, Mechanism of sustained action medication. Theoretical analysis rate of release of solid drugs dispersed in solid matrices, J Pharm Sci, 52, 11451149.
Indian Pharmacopoeia 2007. Ministry of Healthand Family Welfare. Government of India.
Korsmeyer RW., Gurny R., Peppas NA., et al.,1983, Mechanisms of solute release from porous hydrophilic polymers, Int J Pharm, 15, 25-35.
Negi JS., Trivedi A., Khanduri P., et al., 2011, Effect of Bioadhesion on initial in vitro buoyancy of effervescent floating matrix tablets of ciprofloxacin HCl, J. Adv. Pharm. Tech. Res, 2, 121-127.
Owen SC., 2003, Handbook of Pharmaceutical Excipients, The Pharmaceutical Press and
The American Pharmaceutical Association, pp.654-656
Pal TP., Mandal U., Gowda V., et al. 2007, Formulation and Optimization of Sustain release matrix tablets of Metformin Hcl 500 mg using Response Surface Methodology, Yakugaku Zasshi,
Rowe RC., Sheshkey PJ. and Quinn ME., 2009, Handbook of pharmaceutical excipients, 6 e , London: RPS Publication, pp.143. athiyaraj S., Devi RD., Hari and VBN. 2011, Lornoxicam gastroretentive floating matrix tablets: Design and in vitro
evaluation, J Adv Pharm Tech Res, 2 (3),
Shoaib MH., Yousuf RI., and Zaheer K, 2010, Development and Evaluation of Hydrophilic Colloid Matrix of Famotidine Tablets, AAPS Pharm Sci Tech, 11(2), 708-718.
Sudha BS., Sridhar BK., and Srinatha A., 2010, Modulation of Tramadol Release from a
Hydrophobic Matrix: Implications of Formulations and Processing Variables, AAPS Pharm Sci Tech, 11(1), 433-440.
Vijay J., Sahadevan JT., Prabhakaran R., et al., 2012, Formulation and Evaluation of Cephalexin Extended-release Matrix Tablets Using Hydroxy Propyl Methyl
Cellulose as Rate-controlling Polymer, J Young Pharm, 4(1), 3-12. .
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