Drug Related Problem (DRP) of Dengue Hemorragic Fever (DHF) medication in pediatric patient`

Nanang Munif Yasin; Joko Sunowo; Eri Supriyanti

doi:10.14499/indonesianjpharm0iss0pp27-34

Drug Related Problem (DRP) of Dengue Hemorragic Fever (DHF) medication in pediatric patient`

Nanang Munif Yasin, Joko Sunowo, Eri Supriyanti

Abstract

Every year, Dengue Hemorrhagic Fever (DHF) is the big problem Indonesian’s government with high incidency and high mortality. It would increased length of stay and high cost. The objectives of this study are to identify drug-related problems in DHF patient include need for additional drug therapy, unnecessary drug therapy, wrong drug, drug interaction, dosage to high, and dosage too low.

A prospective study of pediatrics admitted to Pediatric Ward, X Private Hospital Yogyakarta for DHF infections was carried out since February-April 2006. Appropriate descriptive analysis was used.

The results showed that unnecessary drug therapy the most drugrelated problems in 22 patient from 65 pediatic patient.The other DRP were dosage too low in 14 patient, dosage too high in 10 patient, wrong drug in 4 patient, and need for additional drug therapy in 2 patient, rescpectively. Antibiotics were the most cause of drug-related problems in DHF patient.

Key words : Dengue Hemorrhagic Fever (DHF), Drug-Related Problem (DRP), Antibiotic , Hospital.

Full Text:

IJPMarch2009_27-34

References

AHFS, 2002, AHFS Drug Information, American Society of health – System Pharmacists, Wisconsin, USA.

Ahmad, K., 2004, Dengue death toll rises in Indonesia, lancet, 363:956.

Aslam, M., Tan, C.K, and Prayitno, A., 2003, Farmasi Klinik, Menuju Pengobatan Rasional dan Penghargaan Pilihan Pasien, 18,192,321,322,325, Elex Media Komputindo, Jakarta.

Cippole, R.. J; Strand, L.M, Morley, P.C; 1998, Pharmaceutical Care Practice,73-101, The Me Graw Hill companies.

Departemen Kesehatan RI, 1990, Petunjuk Pelaksanaan Pengamatan dan Pencegahan Kejadian Luar Biasa Demam Berdarah Dengue (Kewaspadaan Dini), buku II, 9, Dep.Kes.RI., Jakarta.

Departemen Kesehatan RI, 2003, Tatalaksana Demam Berdarah Dengue, 2-4, 9, 11, 13, 15, 17-19, 23, 28, 32, 34, 38, 40, 44, http://www.depkes.go.id, 26 Juli 2006.

Food Drug and Administration, 2004, Advisory Commite for Pharmaceutical Science, http://www.fda.gof/ohrms/dockets/ac/04/transcripts/4034T2.pdf, 18 August 2006.

Gubler, D. J, 1998, Dengue and dengue hemorrhagic fever, Clin Microbiol Rev, 11 : 480-96.

Harrison, 1999, Prinsip-prinsip Ilmu Penyakit Dalam, edisi 13, 100, 1312, EGC, Jakarta.

Hooton, T. M., and Levy, S. B., 2001, Confronting The Antibiotic Resistance Crisis: Making Appropriate Therapeutic Decisions in Community Medical Practice, Medscape Portals, Inc.

Kaushal, R., Bates, D. W., Landringan, C., McKeena, K. J., Clapp, M. D., Federico,F., and Goldmann, D. A., 2001, Medication Errors and Adverse Drug Events in Pediatric inpatient, JAMA; 285: 2114-2120.

Kozer, E., Scolnik, D., Macpherson, A., Keays, T., Shi, K., Luk, T., and Koren G., 2005, Variables Associated With Medication Errors in Pediatric Emergency Medicine, Pediatrics Vol. 110;737-742.

Kristina, Isminah, dan Wulandari L., 2004, Kajian Masalah Kesehatan : Demam Berdarah Dengue, Badan Litbangkes, Depkes RI, Jakarta.

Ngo Thi Nhan, Cao Xuan Thanh Phuong, Rachel Kneen, Bridget Wills, Nguyen Van My, Nguyen Thi Que Phuong, Chu Van Thien, Nguyen Thi Thuy Nga, Julie A.Simpson, Tom

Solomon, Nicholas J. White, and Jeremy Farrar, 2001, Acute Management of Dengue Shock Syndrome: A Randomized Double-Blind Comparison of 4 Intravenous Fluid Regimens in the First Hour, CID; 32: 204-13.

Phillips, J., Beam, S., Brinker, A., Holquist, C., Honig, P., Lee, L.Y., and Pamer, C., 2001, Retrospective Analysis of Mortalities Associated With Medication Errors, American Journal of Health-System Pharmacy, 58 (19):1824-1829.

Setiati, T. E, Wagenaar, J. F. P, de Kruit, M. D, Mairuhu, ATA, van Gorp, ECM, and Soemantri A, 2006, Changing epidemiologi of dengue fever in Indonesia, Dengue Bulletin, 30 : 1-14.

Tatro, D. S., 2001, Drug Interaction Facs, 5th edition, 11,150,285, Facts and Comparation a Wolters Kluwer Company, Missouri.

Tjay, T. H dan Raharja, K., 1993, Swamedikasi, Edisi 1, 42, 43, Departemen Kesehatan RI, Jakarta.

Wallls, T. D., 1997, Kapita Selekta Penyakit dan Terapi, 195, 199, EGC, Jakarta.

WHO, 1997, Dengue haemorrhagic fever : diagnosis, treatment, prevention and control, World Health Organization, 2nd edition, Geneva, Switzerland.

WHO, 1999a, Prevention and control of dengue and dengue haemorrhagic fever comprehensive guidelines, WHO regional publication, SEARO no 29.

WHO, 1999b, Guidelines for Treatment of Dengue Fever/Dengue Haemorrhagic Fever in Small hospital, 6, 20, Regional Office for South-East Asia, WHO, New Delhi.

DOI: http://dx.doi.org/10.14499/indonesianjpharm0iss0pp27-34