Antimalarial  activity  of  ethyl  acetate  extract  of  Garcinia  dulcis kurz stem bark

Gunawan Pamudji Widodo; Mamik Ponco Rahayu

doi:10.14499/indonesianjpharm0iss0pp225-229

Antimalarial activity of ethyl acetate extract of Garcinia dulcis kurz stem bark

Gunawan Pamudji Widodo, Mamik Ponco Rahayu

Abstract

In-vivo antimalarial activity of ethyl acetate extract of Garcinia dulcis Kurz stem bark have been evaluated against Plasmodium berghei induced mice. Antimalarial test was conducted by paracitemia investigation and leucocyte counting of paracite induced mice blood, after oral administration of Garcinia dulcis stem bark extract dose of 25 mg, 50 mg, as well as 75 mg/kg bw. The highest antiplasmodial activity and decresing of leucocyte amount was showed

by extract of dose of 50 mg/kg bw. The compounds identified in ethyl acetate extract of Garcinia dulcis stem bark were flavonoid, saponin and tannin. The compounds that have antimalarial activity weren’t yet known.

Keywords: antimalarial, Garcinia dulcis Kurz, stem bark, paracitemia

Full Text:

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DOI: http://dx.doi.org/10.14499/indonesianjpharm0iss0pp225-229