Antimalarial activity of ethyl acetate extract of Garcinia dulcis kurz stem bark

Gunawan Pamudji Widodo, Mamik Ponco Rahayu

Abstract


In-vivo antimalarial activity of ethyl acetate extract of Garcinia dulcis Kurz stem  bark  have  been  evaluated  against  Plasmodium  berghei  induced  mice. Antimalarial  test  was  conducted  by  paracitemia  investigation  and  leucocyte counting  of  paracite  induced  mice  blood,  after  oral  administration  of  Garcinia dulcis  stem  bark  extract  dose  of  25  mg,  50  mg,  as  well  as  75  mg/kg  bw.  The highest  antiplasmodial  activity  and  decresing  of  leucocyte  amount  was  showed

by  extract  of  dose  of  50  mg/kg  bw.  The  compounds  identified  in  ethyl  acetate extract  of  Garcinia  dulcis  stem  bark  were  flavonoid,  saponin  and  tannin.  The compounds that have antimalarial activity weren’t yet known.

Keywords: antimalarial, Garcinia dulcis Kurz, stem bark, paracitemia


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References


Devi, C.U., Valecha, N., Atul, P.K., and Pillai, P.R., 2001, Antiplasmodial Effect Of Three Medicinal Plants: A Preliminary Study, Current Science, 80 (8), 917-919.

Dewi, R.M., and Sulaksono, E., 1994. Pengaruh Pasase Plasmodium berghei pada Mencit Galur Swiss, Cermin Dunia Kedokteran, 94, 61-63.

Ignatushchenko, M.V., Winter, R.W., Bachinger, H.P., Hinrichs, D.J., and Riscoe, M.K., 1997, Xanthones as antimalarial agents, studies of a Possible Mode of Action, FEBS Letter, 409:67-73.

Lannang, A.M., Komguem, J., Ngninzeko, F.N., Tangmouo, J.G., Lontsi, D., Ajaz, A., Choudhary, M.I., Ranjit, R., Devkota, K.P., and Sodengam, B.L 2005, Bangangxanthone A and B, two xanthones from the Stem bark of Garcinia poliantha Oliv., Phytochemistry, 66, 2351-2355.

Likhitwitayawuid, K., Chanmahasathien, W., Ruangrungsi, N., and Krunkai, J., 1998, Xanthones with antimalarial activity fro Garcinia dulcis, Planta Med, 64, 281-282.

Merza, J., Aumond, M.C., Rondeau, D., Dumontet, V., Ray., A.M.L., and Seraphin, D., dkk., 2004, Prenylated Xanthones and Tocotrienols from Garcinia virgata, Phytochemistry, 65, 2915-2920.

Singgih S., 2009, Panduan Lengkap Menguasai Statistik dengan SPSS 17, Jakarta: PT. Gramedia.

Sukamat and Ersam, T., 2006, Dua Senyawa Santon Dari Kayu Batang Mundu Garcinia Dulcis (Roxb.) Kurz. Sebagai Antioksidan. Makalah disajikan dalam Seminar Nasional Kimia VIII, Surabaya, 8 Agustus.

Syamsudin, Tjokrosonto, S., Wahyuono, S., and Mustofa, 2007, Aktivitas antiplasmodium dari dua fraksi ekstrak n-heksana kulit batang asam kandis (Garcinia parvifolia Miq), Majalah Farmasi Indonesia, 18(4), 210– 215.




DOI: http://dx.doi.org/10.14499/indonesianjpharm0iss0pp225-229

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