Profile of sulphacetamide pharmacokinetics on uranyl nitrate-induced renal failure rats

Djoko Wahyono, Arief Rahman Hakim, Agung Endro Nugroho

Abstract


Kidney is a vital organ which has main function to maintain the body homeostasis. The role of kidney is the excretion (elimination) of waste product, and if there is pathologically a renal failure so will change the drug pharmacokinetics and in turn change it’s potency. The present study evaluated the effect of uranyl nitrate-induced renal failure on the pharmacokinetics profiles of sulphacetamide in rats.

The study was conducted by employing a completely randomized design in male Wistar in bred rat (aged 2-2.5 months, 150-250 g). The animals in group I were given sulphacetamide sodium with an oral single dose 100.0 mg/kg BW (control group) and in group II were given pretreatment with uranyl nitrate at 3 days before sulphacetamide administration.

After collected at some certain times, the drug concentrations on bloods were analyzed by an ultraviolet spectrophometer. The results have shown that uranyl nitrate-induced renal failure decreased the primer pharmacokinetics parameter i.e. total clearance (ClT) and volume of distribution in steady state (Vdss), significantly (P<0.05). The decreasing of these parameter could cause alteration of the secondary pharmacokinetics parameters of sulphacetamide and these derivates i.e. Cmax, tmax, AUC0-240, AUC0-inf, MRT, K and t1/2 elimination significantly (P<0.05). According from the results, it is concluded that uranyl nitrate-induced renal failure affected the pharmacokinetics of sulphacetamide or could increase the sulphacetamide concentration in blood.

Key words : sulphacetamide, pharmacokinetics, renal failure, uranyl nitrate


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References


Annino, J. S., 1964, An Observation Concerning the Bratton-Marshall Diazo Reaction in Sulfonamide-free Urine, Clinical Chemistry, 10, 370-371.

Atkinson, J. A, Daniels, E. C., Dedrick L. R., Grudzinskas, V. C., and Markey, P. S.,2001, Principles of Clinical Pharmacology, San Diego, California.

Brody, T. M., Larner, J. L., Minneman, K. P., and Neu, H. C. (Ed.), 1994, Human Pharmacology, 2nd Ed., Mosby, Sydney.

Benedetti P. G., 1987, Structure-activity relationships and mechanism of action of antibacterial sulphanilamides and solphones, dalam : Testa B. (ed), Advances in drug research, vol. 16, Academic Press, Harcourt Brace Jovanovich Publisher, London.

Brunton L. L., 2006, Goodman and Gilman’s The Pharmacological Basis of Therapeutics, 11th Ed., McGraw- Hill, New York.

Dollery C., 1999, Therapeutic Drugs, 2st ed., vol. II, s124-s126, Churchill Livingstone, Edinburg.

Evaria, and Salomon E., 2004, MIMS Indonesia petunjuk konsultasi, PT. InfoMaster, Jakarta.

Johnston, A., and Woollard, R. C., 1983, STRIPE: A Computer Program for Pharmacokinetics, J. Pharmacol. Meth., 9: 193-200

Jung, D. T., 1984, Stripe, College of Pharmacy University of Illinois, Chicago.

Klimowicz A., 1988, Comparison of four methods for the determination of sulphonamide concentration in human plasma, Meth. Find. Clin. Pharmacol. 10(5) : 331-336

Lee A. K., Kim E. J., and Lee M. G., 2003, Effects of acute renal failure induced by uranyl nitrate on the pharmacokinetics of intravenous torasemide in rats, Res. Commun. Mol. Pathol. Pharmacol., 113-114 : 193-200.

Lee A. K., Lee J. H., Kwon J. W., Kim W. B., Kim S. G., Kim S. H., and Lee M. G., 2004, Pharmacokinetics of clarithromycin in rats with acute renal failure induced by uranyl nitrate, Biopharm. Drug Dispos., 25(6) : 273-282

Mueller B. A., 2005, Acute Renal Failure, dalam Dipiro J. T., Talbert R.. L., Yee G. C., Matzke G. R., Wells B. G., Posey L. M., Pharmacoterapy A Pathophysiologic Approach, 6th ed., McGraw-Hill, New York.

Rowland, M. and Tozer., T. M., 1989, Clinical Pharmacokinetics : Concept and Application, 2nd Ed., 9-65, 246-266, Lea and Febiger, Philadelphia.

Shargel, L. and Yu, A. B. C., 1993, Applied Biopharmaceutics and Pharmacokinetics, 3rd Ed, Appleton and Lange, Norwalk, Connecticut, New York.

Sun, D. F., Fujigaki, Y., Fujimoto, T., Yonemura, K., and Hishida, A., 2000, Possible involvement of myofibroblasts in cellular recovery of uranyl acetate-induced acute renal failure in rats, Am. J., Pathol., 157(4) : 1321-1335

Wilson, L. M., 1992, Gagal Ginjal Kronik, dalam Price, S. A. dan Wilson, L. M., Patofisiologi, diterjemahkan oleh Peter A., Buku II, ed. IV, 812-845, Penerbit Buku Kedokteran EGC, Jakara.

Williams R.. L., Brater D. C., and Mordenti J., 1990, Rational therapy, Marcell Dekker Inc., New York.

Yoshitani T., Yagi H., Inotsume N., and Yasuhara M., 2002, Effect of experimental renal failure on the pharmacokinetics of losartan in rats, Biol. Pharm. Bull., 25(8) : 1077-1083.

Yu S. Y., Chung H. C., Kim E. J., Lee I., Kim S. G., and Lee M. G., 2002, Effects of acute renal failure induced by uranyl nitrate on the pharmacokinetics of intravenous theophylline in rats : the role of CYP2E1 induction in 1,3-dimethyluric acid formation, J. Pharm. Pharmacol., 54(12) : 1687-1692.




DOI: http://dx.doi.org/10.14499/indonesianjpharm0iss0pp117-123

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