Effect of the combination of C.domestica extract and essential oil of C.xanthorrhiza roxb. on leucocyte count in synovial fluid compared to that of pyroxicam

Nyoman Kertia; Imono A.D.; Mufrod .; Eny Catur; Poerwono Rahardjo; Ahmad Husain Asdie

doi:10.14499/indonesianjpharm0iss0pp155-161

Effect of the combination of C.domestica extract and essential oil of C.xanthorrhiza roxb. on leucocyte count in synovial fluid compared to that of pyroxicam

Nyoman Kertia, Imono A.D., Mufrod ., Eny Catur, Poerwono Rahardjo, Ahmad Husain Asdie

Abstract

Osteoarthritis (OA) is the most prevalence rheumatic disease. The non steroidal antiinflamatory drugs display some side effect especially on the gastrointestinal tract, liver, kidney and blood clotting. Kunyit (Curcuma domestica L.) and temulawak (Curcuma xanthorrhiza Roxb.) as natural
herbal remedies are developed for antiinflammation, antioxidant and cholagoga. The aim of this present research was to study the effect of combination of Curcuma domestica extract and essential oil of Curcuma xanthorrhiza Roxb on the leucocyte count in the synovial fluid of patient with osteoarthritis compared to that of pyroxicam. A double blind randomized
clinical trial was used and conducted at Dr. Sardjito Hospital Yogyakarta. After washed out period the knee synovial fluid was aspirated and the leucocyte count was examined. Patients were randomized for receiving piroxicam capsule 10 mg twice daily or combination of 3,66 ± 0,65 % w/w
curcuminoid extract of Curcuma domestica L.and 25 ml essential oil containing curcumen, bergamoten germacren B, Curserenon, Germacron, Xanthorrizol as a major component with 27,64 ± 0,85 % relative concentration of xanthorrhizol each capsule; two times a day for two week period. At the end of this study the synovial fluid was examined.
Decreasing the inflamation of synovial area was parrallel with decreasing leucocyte count by 174.56 ± 161.73 per mm3 (p<0.01) in the pyroxicam treatment group and 182,37 ± 126,5 per mm3 (p<0,01) in the combination of curcumine extract of kunyit and essential oil of Temulawak treatment group. There was no significant difference on decreasing of leucocyte count between pyroxicam and the combination of the curcuminoid extract of C. domestica and the essential oil of the Curcuma xanthorrhiza treatment.
Key words: Combination of Curcuminoid extract of Curcumae longae Rhizoms and essential oil of Curcumae xanthorrhizae Rhizome, sinovial fluid leucocyte Count.

Full Text:

Untitled

References

Agnam, N., Samhoedi, H., Timmerman, H., Venie, U.A., Sugiyanto., Goot, h., 1995, The Relationship between Structure and Inhibition of Lipoxygenase activity of Curcumin derivates in International Symposium on Curcumin Pharmaco chemistry (ISCP), Yogyakarta

De Haan, 1949, Therapie Compendium (Receptuur voor de Huijsarts), D.B.,Centen’s Uitgevers Mij, Amsterdam.

Hadi S., 1996, Khasiat Fitofarmaka Pada Hepatitis dalam Simposium Hepatitis, Yogyakarta

Harini, M.S., Ervizal A.M., Ellyn K.D., 2000, Kamus Penyakit dan Tumbuhan Obat Indonesia (Etnofitomedika), Yayasan Obor Indonesia.

Isbagyo.H.,1994, Osteoartritis Dalam Buku Ajar Ilmu Penyakit Dalam hal. 680 688, Jakarta

Kalim H., 1996 Penyakit Sendi Degeneratif(Osteoarthritis), Dalam Buku Ajar Ilmu Penyakit Dalam 74-86, Jakarta

Lazarowych, 1998, Use of fingerprinting and Marker Compounds for identification and Standardization of Botanical Drugs, Drug Information Journal, 32, 497-512 ed., Lea & Febiger; Philadelphia

Rahardjo P.,1994, Masalah dan Penanganan Osteoartritis Konggres Ahli Rematologi Indonesia,

Loomis, T.A., 1978, Essentials of Toxicology, 3rd Palembang

Schneider G., 1985, Pharmazeutische Biologie, B.I.Wissenschaftsverlag, Mannheim hal

Soenarto, 1994, Pengobatan Penyakit Rematik dengan Obat Antiinflamasi Dalam Buku Ajar Ilmu Penyakit Dalam, 764-766, Jakarta

Timmerman, H., 1995 New perspective for antiinflammatory drugs in International Symposium on Curcumin Pharmacochemistry (ISCP)., Yogyakarta.

DOI: http://dx.doi.org/10.14499/indonesianjpharm0iss0pp155-161