Adverse drug reactions (ADRs) pada pasien rawat inap geriatri

Fita Rahmawati, I Dewa Putu Pramantara, Wasilah Rochmah, Syed Azhar Syed Sulaiman

Abstract


Adverse drug reactions (ADRs) merupakan masalah yang sering terjadi pada pasien lanjut usia. Penelitian bertujuan mengetahui angka kejadian adverse drug reactions pada pasien rawat inap geriatri.

Penelitian dilakukan dengan mengambil data secara prospektif pada 100 pasien rawat inap geriatric dengan kriteria usia pasien 60 tahun atau lebih dan menjalani rawat inap di bagian Penyakit Dalam (IRNA1) RSUP Dr. Sardjito Yogyakarta pada dua periode waktu (Januari–Februari 2006 dan Agustus–Oktober 2006). Pengambilan data dilakukan melalui catatan medic kemudian identifikasi efek samping obat dilakukan melalui diskusi farmasis dengan klinisi konsultan geriatri. Evaluasi data dilakukan secara descriptive Hasil penelitian menunjukkan bahwa ADRs diduga kuat dialami oleh 25 pasien dengan total 30 kejadian ADRs. Sebagian besar ADRs yang ditemukan berhubungan dengan gangguan pada gastrointestinal (mual, muntah, dispepsia, konstipasi, diare dan gastritis) 56,7.% dan kardiovaskular (hipertensi dan hipotensi) 16,7.%. Farmasis dapat berperan dalam identifikasi ADRs melalui kolaborasi dengan tenaga kesehatan lain di rumah sakit sehingga dapat dilakukan upaya pencegahan terhadap ADRs pada pasien geriatri

Kata kunci: Adverse drug reactions (ADRs), Geriatri, Rawat inap.


Full Text:

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References


Anonim, 2005, Nausea and vomiting treatment guidelines for patients with cancer, Version III, National Comprehensive Cancer Network. 9

Anonim, 2007, Usia Harapan Hidup di Yogyakarta Tertinggi, accessed http://www.suara merdeka.com/harian/0712/28/ked02.htm, 7 November 2008.

Bates, D.W., Spell, N., and Cullen, D.J., 1997, The cost of adverse drug events in hospital patients. JAMA, 277, 300-311

Bednall, R., 2003, Drug-related problems may bring thousands to A&E departments, The Pharmaceutical Journal , 270, 7240, 359.

Col, N., Fanale, J. E. and Keonholm, P., 1990, The role of medication in noncompliance and adverse drug reactions in hospitalizations of the elderly, Arch Intern Med ,150, 841-845

Classen, D. C., Pestotnik, S.L. and Evans, R.S., 1997, Adverse drug events in hospitalized patients, JAMA, 277, 301-306

Gharaibeh, M.N., Greenberg, H.E., and Waldman, S.A, 1998, Adverse drug reactions: a review, Drug Information Journal, 32, 323-338.

Giron, M.S.T., Claesson, C., Thorslund, M., Oke, T., Winblad, B. and Fastbom, J., 1999, Drug Use Patterns in a Very Elderly Population: A Seven-Year Review, Clin Drug Invest , 17(5), 389-398

Helper, C. D., and Strand, L.M., 1990, Opportunities and responsibilities in pharmaceutical care. Am J Hosp Pharm, Vol. 47, 533-43.

Hohl, C. M., Dankoff, J., Colacone, A., and Afilavo, M., 2001, Polypharmacy, adverse drug-related events and potential adverse drug interaction in elderly patients presenting to an emergency department, Annals of emergency medicine, 38 , 666- 671.

Hudson, S.A., and Boyter, A.C., 1997, Pharmaceutical care of the elderly, The Pharmaceutical Journal , 259, 686-688.

Hurwitz, N., 1969, Predisposing factors in adverse reactions to drugs, Br Med J , 1, 536-9.

Leape, L.L., Brennan, T.A., Laird, N.M., Lawthers, A.G., Localio, A.R., and Barnes, B.A., 1991, The nature of adverse events in hospitalized patients. Results of the Harvard medical practice study II, N Engl J Med , 324, 37784.

Larsen, P.D. and Martin, J.H., 1999, Polypharmacy and elderly patient, AORN Journal, www.findarticles.com, accessed on December 18 th , 2004

Nair, B., 1999, Older people and medications: what is the right prescription?, Aust Prescr, 22, 130-131

Semla, T. P., Beizer, J. L. and Higbee, M.D., 2004, Geriatric dosage handbook, 9 th ed, Lexi-Comp Inc, USA

Walker, J. and Wynne ,H., 1994, Review: the frequency and severity of adverse drug reactions in elderly people, Age and ageing, 23, No. 3, 255-259, http://findarticles.com/p/ articles/ mi_m2459/is_n3_v23/ai_15465854

Williamson, J. and Chopin, J.M., 1980, Adverse reactions to prescribed drugs in the elderly: a multicentre investigation. Age Ageing , 9, 73-80.

Wiffen, P., Mitchell, M., Snelling, M. and Stoner, N., 2007, Oxford Handbook of Clinical Pharmacy, Oxford University Press Inc., New York United Sates, 18-22.




DOI: http://dx.doi.org/10.14499/indonesianjpharm0iss0pp185-190

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