Hypocholesterolemic and hypoglicemic effects of butyrylated arrowroot starch on Sprague Dawley rats
The aim of research is to investigate the hypocholesterolemic and hypoglicemic effects of butyrylated arrowroot starch in rat. The study was carried out using 30 Sprague Dawley rats which were divided into 5 groups of six rats. Each group was fed with different diets, i.e. diet containing butyrylated arrowroot starch with different degrees of substitution (DS of 0; 0.053; 0.120 and 0.187) and standard diet (AIN93). After 34 days feeding, the rats were killed and the blood was taken and analyzed for total cholesterol, triglyceride, LDL cholesterol, HDL cholesterol, and glucose concentrations. The result showed that rats fed with diet containing butyrylated arrowroot starch had lower concentration of total cholesterol, LDL cholesterol, glucose, and triglyceride, but the HDL cholesterol concentration was higher than those fed with arrowroot starch and standard diet AIN93. The higher the degree of substitution of the starch in the diet gave improved on those parameters. Butyrylated arrowroot starch has hypocholesterolemic and hypoglycemic effect.
Key word: Butyrylated arrowroot starch, hypocholesterolemic, hypoglicemic
Annison, G., Illman, R. J. and Topping, D. L. 2003. Acetylated, propionylated or butyrylated starches raise large bowel short-chain fatty acids preferentially when fed to rats. J. Nutr. 133 : 3523-3528.
Behall, K. M., Scholfield, D. J. Hallfrisch, J. G. and Liljeberg-Elmstahl, H. G. M. 2006. Consumption of both resistant starch and ß-glucan improves postprandial plasma glucose and insulin in women. Diabetes Care 29 : 976–981.
Cheng, H. H and Lai, M. H. 2000. Fermentation of resistant rice starch produces propionate reducing serum and hepatic cholesterol in rats. J. Nutr. 130 : 1991–1995.
Eckel, W.. Stone, P., Ellis and Colwell. 1977. Cholesterol determinan in high density lipoprotein separated by three different methods, Clinic Chem. 23 : 882-884.
Englyst, H. N., Kingman, S. M. and Cummings, J. H., 1992. Classification and measurement of nutritionally important starch fractions. In: Asp (ed): Resistant Starch : Proceeding from the 2 nd plenary meeting of EURESTA. Eur. J. Clin. Nutr. 46 : S33-S50.
Han, K., Sekikawa, M., Shimada, K., Sasaki, K., Ohba, K. and M. Fukushima. 2004. Resistant starch fraction prepared from kintoki bean affects gene expression of genes associated with cholesterol metabolism in rats. Exp Biol Med 229 : 787–792.
Haryadi. 2003. Amyllolitic degradation sites of hydroxypropyl starch. Procedings Starch Update 2003, 12 – 20 July 2003, Pattaya.
Heacock, P. M., Hertzlera, S. R. and Wolf, B. 2004. The glycemic, insulinemic, and breath hydrogen responses in humans to a food starch esterified by 1-octenyl succinic anhydride. Nutrition Research 24 : 581–592
Kishida, T., Nogami, H., Ogawa, H. and Ebihara, K. 2002. The hypocholesterolemic effect of high amylose cornstarch in rats is mediated by an enlarged bile acid pool and increased fecal bile acid excretion, not by cecal fermented products. J. Nutr. 132: 2519–2524.
Marsono, Y, Wiyono, P. and Utama, Z. 2007. Indek glikemik produk olahan garut (Maranta arundinacea LINN). Proseding Seminar Nasional PATPI, Bandung 17–18 Juli 2007.
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