EVALUATION OF IMMUNOMODULATORY ACTIVITY OF SESBANIA GRANDIFLORA FLOWERS EXTRACT IN MICE
The aim of the present study was to investigate the immunomodulatory activity of Sesbania grandiflora on cellular and humoral immunity. Oral administration of the methanolic extract (200 and 400mg/kg) of S. grandiflora flowers, in mice, dose-dependently significantly enhanced the production of circulating antibody titre in mice in response to SRBC. It significantly potentiated the delayed-type hypersensitivity reaction induced by sheep red blood cells (SRBC). Good response was also found towards phagocytosis in carbon clearance assay and prevented myelosuppression in cyclophosphamide drug. Aqueous extract at 250mg/kg dose level failed to show immunomodulatory activity but 500mg/kg of aqueous extract potentiated the activity however less significantly compared with both dose of methanolic extract. The results obtained in this study indicate that methanolic extract (400mg/kg) of S. grandiflora possesses potential immunomodulatory activity.
Full Text:PDF (PP.277-283)
Bafna AR, Mishra SH., 2004. Immunomodulatory Activity of Methanol Extract of Flower-Heads of Sphaeranthus indicus Linn. Ars. Pharm. 45: 281-291.
Burbidage NT., 1965. Australian species of S. scop (leguminosae). Aus. J. Botany 13: 103–141.
Damre AS, Gokhale AB, Phadke AS, Kulkarni, KR, Saraf M 2003. Studies on the immunomodulatory activity of flavonoidal fraction of Tephrosia purpurea. Fitoterapia, 749: 257-260.
Dhumal JS., Yele SU., Ghodekar SN. 2013. Evaluation of immunomodulatory activity of Vigna mungo (L) hepper. J Pharm Phytother, 2: 9 – 14.
Doddola S., Pasupulati H., Koganti B., Prasad KV., 2008. Evaluation of S. grandiflora for antiurolithiatic and antioxidant properties. J Nat. Med. 62: 300–307.
Gautama G., Sahaa S., Banib S., Kaulb A., Mishraa S., Patil D., et al. 2009. Immunomodulatory activity of Asparagus racemosus on systemic Th1/Th2immunity: implications for immunoadjuvant potential. J. Ethnopharmacol; 121: 241-247.
Gokhale AB, Damre AS., Saraf MN. 2003. Investigations into the immunomodulatory activity of Argyreia speciosa. J. Ethnopharmacology 84: 109-114.
Miller LE., 1991. In: Ludke, H.R., Peacock, J.E., Tomar, R.H. (Eds.), Manual of Laboratory Immunology. Lea and Febiger, London, pp. 1–18.
Patwardhan B., Kalbagh D., Patki PS., Nagsampagi BA., 1990. Search of immunomodulatory agents: a review. Indian Drugs. 28: 56–63.
Satnam S., Yadav CPS., Malleshappa NN., 2012. Asian Pac J. Trop. Biomed; 2(6): 433-437.
Shinde UA., Phadke AS., Nair AM., Mungantiwar AA., Dikshit VJ., Saraf MN., 1999. Preliminary studies on the immunomodulatory activity of Cedrus deodara wood oil, Fitoterapia. 70: 333-339.
Shivaprasad HN., Kharya MD., Rana AC., Mohan S., 2006. Preliminary immunomodulatory activities of aqueous extract of Terminalia chebula. Pharmaceutical Biology. 44: 32–34.
Shukla S., Mehta A., Johna J., Mehtaa P., et al. 2009. Immunomodulatory activities of the ethanolic extract of Caesalpinia bonducella seeds. J. Ethnopharmacology 125: 252–256.
Sreelatha S., Padma PR., Umasankari E. 2011. Evaluation of anticancer activity of ethanol extract of S. grandiflora (Agati Sesban) against Ehrlich ascites carcinoma in Swiss albino mice. J Ethnopharmacol; 134: 984-987.
Thakur M., Bhargava S., Dixit VK., 2006 Immunomodulatory activity of Chlorophytum borivilianum Sant., eCAM
Trease GE., Evans MC., 1983. Textbook of Pharmacognosy, 12th ed. Balliere, Tindall, London, pp. 343–383.
Yadav R., Kharya DM., Yadav N., Savadi R. 2011. Immunomodulatory potential of ethanol extract of Spilanthus acmella leaves Int. J. Biol. Med. Res; 2(3): 631-635
- There are currently no refbacks.
Copyright (c) 2017 INDONESIAN JOURNAL OF PHARMACY
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Indonesian J Pharm indexed by:View My Stats