THE APPLICATION OF HYDROTROPES AS MEDIUM IN THE EXTRACTION OF ANDROGRAPHOLIDE

Indah Hartati, Laeli Kurniasari, Yance Anas, Nur Aniq

Abstract


Hydrotrope solutions provide safe and effective media for the microwave assisted extraction of andrographolide, the major bioactive chemical constituent of plant Andrographis paniculata. Microwave assisted extraction of androgpaholide was carried out by using hydrotropes, sodium benzoate and urea. The objective of this work were to determine the Minimum Hydrotrope Concentration (MHC) and to determine the effectiveness of each hydrotrope with respect to andrographolide at different system powers. The microwave assisted extractions of andrographolide were carried out at different concentration of hydrotropes (0.2-3M) and different system powers (39.9 and 119.7 Watt). Twenty grams of Andrographis paniculata dried powder were added to 200 ml of hydrotrope solutions and extracted in a microwave extractor for 15 minutes. The research result showed that the percentage of the microwave assisted extraction of andrographolide by using sodium benzoate and urea were up to 10.9% and 1.05% respectively. The Minimum Hydrotrope Concentration and the effectiveness of hydrotropes that was measured in term of Setschenow constant (Ks) were reported for two hydrotropes used in this study. 


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References


Anju, D., Jugnu, G., Kavita, S., Arun, N. and Sandeep, D. 2012. A Review on medical Prospectives of Andrographis Panuculata Nees. J.Pharm. Sci. Inn... I(I):1-4

Avanigadda, S. and Vangalapati, M. 2010. Experimental and Modelling of Andrographolide Extraction From Andrographis Paniculata. Int. J. Chem, Environmental and Pharmaceutical Res. Vol 1, 32-36

Bharati, B.D., Sharma, P.K., Kumar, N., Dudhe, R. and Bansal, V. 2011. Pharmacological Activity of Andrographis Paniculata: A Brief Review. Pharmacologyonline. 2. 1:10

Das, S., Mukhopadhyay, A.K. and Basu, D. 2009. Prospect of Microwave Processing: An Overview. Bulletin of Material Science, 32(1):1-13.

Dhinakaran M., Morais, A.B. and Gandhi, N.N. 2012. Reflection of Hydrotropy Technique in the Segregation of 1,1/1,2-Diphenylethane. Af. J. Basic and Applied Sciences 4 (2): 55-59

Dongre, P.P., Kannur, D.M., Kosambiya, V. And Desai, B.D. 2011. Significant Role Of Hydrotropes In Extraction Of Phytoconstituents- A Review. Int. J. Pharm. Sci. Res. Vol. 2(4): 730-734

Jayakumar, C., Morais, A.B., Sreenivasan, D., Jayesh, N.G. 2012. Effect Of Hydrotropes On Solubility And Mass Transfer Coefficient Of 1, 2- Dichloroethane. Int. J. Chem. Eng. and App. Sci., 2(1): 6-12

Kumoro, A.C. and Hasan, M. 2007. Supercritical CO2 Extraction of Andrographolide from Andrographis paniculata: Effect of the Solvent Flow Rate, Pressure, and Temperature. China Journal of Chemical Engineering, Vol 15: 877-883

Lomlin, L., Jirayupong, N. and Plubrukan, A. 2003. Heat Accelerated Degradation of Solid State Andrographolide. Chemical Pharmaceutical Bulletin, Vol 51, 24-26

Raman, G. and Gaikar, V.2002. Extraction of Piperine from Piper nigrum (Black Pepper) by Hydrotropic Solubilization. Ind. Eng. Chem. Res. 41. 2966-2976

US Patent no 7341748. Crude extracts from Andrographis paniculata.

US Patent no 6224877.Process for extraction of curcuminoids from curcuma species.

Varma, A., Padh, H. And Shrivastava, N. 2011. Andrographolide: A New Plant Derived Antineoplastic Entity on Horizone. Evidence based Complementary and Alternative Medicine, Vol 2011, 1-9

Vasu, S., Palaniyappan, V., Shrishaillapa. 2010. A novel microwave-assisted extraction for the isolation of andrographolide from Andrographis paniculata and its in vitro antioxidant activity. Natural Product Research Volume 24, Issue 16, 2010

Wongkittipong,R., Prat, L., Damronglerd, S. and Gourdon, C. 2004. Solid Liquid Extraction of Andrographolide From Plants-Experimental Study, Kinetics Reaction and Model”, Royal Golden Jubilee Scholarship Program




DOI: http://dx.doi.org/10.14499/indonesianjpharm25iss4pp265

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