SYNTHESES AND ANTIOXIDANT ACTIVITIES OF SOME HYDROXY DIMETHOXY CHALCONE DERIVATIVES

Elfi Susanti VH

Abstract


Four (4) hydroxy dimethoxy chalcones derivatives were synthesized by Claisen-Schmidt condensation of hydroxyacetophenone with 3,4-dimethoxybenzaldehyde using conventional method and grinding technique. The synthesized compounds were characterized by spectroscopy (IR, 1H-NMR and 13C-NMR). Synthesis of the hydroxy dimethoxy chalcone using grinding method is better than the conventional method. The synthesis using grinding method require a low concentration base, shorter reaction (15min) and higher yield (70-84%).  The antioxidant activity of the compounds was determined by DPPH method, showed that  2',5'-dihydroxy-3,4-dimethoxy chalcone have the highest antioxidant activity.

Key word: hydroxy dimethoxy chalcone, Claisen-Schmidt condensation, grinding, DPPH method


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DOI: http://dx.doi.org/10.14499/indonesianjpharm25iss1pp17

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