Effect of Lipid Ratio of Stearic Acid and Oleic Acid on Characteristics of Nanostructure Lipid Carrier (NLC) System of Diethylammonium Diclofenac

Esti Hendradi, Noorma Rosita, Erwinda Rahmadhanniar

Abstract


The aim of this study was to determine the effect of lipid ratio of stearic acid and oleic acid on the physical characteristics as well as the entrapment efficiency of diethylammonium diclofenac with Nanostructure Lipid Carrier (NLC) system. Diethylammonium diclofenac (DETA) is Non-Steroid Anti-Inflamatory Drugs (NSAIDs) that has been widely used in the treatment of osteoarthritis and rheumatoid arthritis. In the formulation of NLC-DETA, three different lipid ratios were used, which the ratio of  stearic acid:oleic acid were 60:40, 70:30, and 80:20, respectively. In this NLC system, DETA served as the active drug, stearic acid as solid lipid, oleic acid as liquid lipid, and Tween 80 as surfactant components. NLC were characterized for organoleptic characteristics, pH, viscosity, particle morphology, particle size and polydispersity index (PI), profiles of Fourier Transform Infra-Red (FTIR) and Differential Thermal Analysis (DTA), and drug entrapment efficiency. The particle shape and morphology were determined by Transmission Electron Microscopy (TEM). The results  showed that the different ratios of oleic acid lipids and stearic acid had no significant effects on the viscosity and entrapment efficiency of NLC-DETA. On the other hand, it affected the pH of all formulas, which were significantly different. Increasing the amount of liquid lipid in the formulations reduced the size of NLC-DETA particles. 


Keywords


DETA, NLC, physicochemical characterization, entrapment efficiency

Full Text:

PDF

References


Anggraeni, Y., Haryanto, IY., Hendradi, E., 2017. Physical and chemical characteristics of meloxicam from nanostructured lipid carriers system using some concentration ratios of monostearin and alpha-tocopherol acetate lipid matrix. Asian J Pharm Clin Res, Vol 10, Issue 2, 2017, 132-137

Fini, A., Bassini, G., Monastero, A., Cavallari, C., 2012. Diclofenac Salts, VIII. Effect of the Counterions on the Permeation through Porcine Membrane from Aqueous Saturated Solutions. J Pharmaceutics, Vol. 4, p. 413-429.

Gunawan, SG., Setiabudy, R., Nafrialdi, & Elysabeth., 2007. Farmakologi dan Terapi, Edisi 5, Jakarta: Balai Penerbit FKUI, hal 230-233.

Hussain Shah, SN., Salman, M., Ahmad, M., 2012. Effect of Oleic Acid on the Permeation Kinetics of Diclofenac Diethylamine. J Chem Soc Pak, No.1, Vol. 34

Jorge, LL., Feres, CC., Vitor, EP., 2010. Topical Preparations for Pain Relief: Efficacy and Patient Adherence. J Pain Res, Vol. 4, p. 11-24.

Meghana, SK., Vaidya, KK., Bhosale, AV., Chaundari, PD., 2012. Solid Lipid Nanoparticles and Nano Structure Carriers : An Overview. Int J Pharm Chem Bio Scie. Vol. 2(4), p. 681-691.

Okyar, A., Özsoy, Y., Güngör, S., 2012. Novel Formulation Approaches for Dermal and Transdermal Delivery of Non-Steroidal Anti-Inflamatory Drugs. Intech Open Scince Mind.

Patel, D., Dasgupta, S., Dey, S., Ramani, Y. R., 2012. Nano-structured Lipid Carriers (NLC)-Based Gel for the Topical Delivery of Aceclofenac: Preparation, Charac-terization, and In Vivo Evaluation. Scientia Pharmaceutica, p. 749-764.

Phatak, AA. Chaudari, PD., 2013. Development and evaluation of nanostructured Lipid Carrier (NLC) Based Topical Delivery of an Anti-Inflammatory Drug. J Pharm Res, p. 677-685

Putranti, AR., primaharinastiti, R., Hendradi, E., 2017. Effectivity and physicochemical stability of nanostructured lipid carrier coenzyme Q10 in different ratio of lipid cetyl palmitate and alpha tocopheryl acetate as carrier. Asian J Pharm Clinical Res, Vol 10, Issue 2, 2017, 1-7.

Shinde, G., Rajesh, KS., Prajapati, N., Murthy, RSR., 2013. Formulation, Development and Characterization of Nanostructured Lipid Carrier (NLC) Loaded Gel for Psoriasis. Scholar Research Library, p. 13-25.

Sweetman, SC., 2009. Martindale The Complete Drug Reference, 36th ed., London : Pharmaceutical Press (PhP), p. 17, 44-47, 59.




DOI: http://dx.doi.org/10.14499/indonesianjpharm28iss4pp198

Refbacks

  • There are currently no refbacks.




Copyright (c) 2018 INDONESIAN JOURNAL OF PHARMACY

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Indonesian J Pharm indexed by:

                                    
 
web
analytics View My Stats