Swamykannu Dinesh Mohan


The purpose of present work was to formulate Fluconazole loaded microsponge-based topical delivery system for modified release. Microsponges with varied drug–polymer ratios were prepared by emulsion solvent diffusion technique using Ethyl cellulose as release retard material. Prepared microsponges were studied for particle size and physical characterization. Scanning electron microscopy (SEM) images showed the microsponges porous and spherical in shape. The microsponges were then incorporated in carbopol gel and evaluated for pH, viscosity, spreadability, drug content, in-vitro release. The In vitro drug release showed that microsponges with 1:1.5 drug–polymer ratios (F3) were more efficient to give sustained release of 74.2% at the end of 8 hr. All the microsponge gel formulations (i.e.F1- F10) showed better results like pH between 6.5-7.0, viscosity between 25,030-47,390 cps, spreadability 2-4 cm/s and drug content of 76.20±0.02% to 96.41±0.01%.  Hence, the fabricated microsponge based formulation of Fluconazole would be anticipation and promising substitute to conventional therapy of skin infections.


Fluconazole, Microsponge, Ethyl cellulose, Scanning electron microscopy and Zero order kinetics


Vinod L. Gaikwad, Vishal D.Yadav, Rakesh P. Dhavale, Prafulla B. Choudhari, Swapnil D Jadhav 'Effect of Carbopol 934 and 940 on Fluconazole Release from Topical Gel Formulation', C.P.R. 2012; 2(2) p.487- 493,

Doaa A. Helal, Dalia Abd El-Rhman, Sally A. Abdel-Halim, Mohamed A. El-Nabarawi Formulation and evaluation of Fluconazole topical gel Int J Pharm Pharm Sci, v4, (Suppl 5), p176-183,

Niethard, F.U., Gold, M.S., Solomon, G.S., Liu, J.M., Unkauf, M., Albrecht, H.H., Elkik, F., 2005. Efficacy of topical diclofenac diethylamine gel in osteoarthritis of the knee. J. Rheumatol. v32, p2384–2392,

Kulkarni, R.V., Wagh, Y.J., Setty, C.M., Sa, B., 2011. Development and characterization of sodium alginate hydroxypropyl methylcellulose-polyester multilayered hydrogel membranes for drug delivery through skin. Polym.-Plast. Technol. Eng. v50, p490–497,

D’souza, J.I., More, H.N., 2008. Topical anti-inflammatory gels of fluocinolone acetonide entrapped in eudragit based microsponge delivery system. Res. J. Pharm. Technol. v1, p502–506,

Vyas, L.K., Tapar, K.K., Laddha, B.H., Lahoti, A.O., Nema, R.K., 2010. Formulation and development of anti-blemish preparations using microsponge technology. J. Chem. Pharm. Res. v2, p562–571,

Vyas, S.P., Khar, R.K., 2002. Targeted and Controlled Drug Delivery Novel Carrier System, 1st ed. CBS Publication, New Delhi

Won, R. 1987. Method for delivering an active ingredient by controlled time release utilizing a novel delivery vehicle which can be prepared by a process utilizing the active ingredient as a porogen. U.S. Patent 4,690,825

Orlu M, Cevher E, Araman A. 2006 Design and evaluation of colon specific drug delivery system containing flurbiprofen microsponges. Int J Pharm. v318 p103–17,

Nokhodchi, A., Jelvehgari, M., Reza, S.M., Reza, M.M., 2007. Factors affecting the morphology of benzoyl peroxide microsponges. Micron v38, p834–840,

Kilicarslan, M., Baykara, T., 2003. The effect of the drug/polymer ratio on the properties of verapamil hydrochloride loaded microspheres. Int. J. Pharm. v252, p99–109,

Mine, O., Erdal, C., Ahmet, A., 2006. Design and evaluation of colon specific drug delivery system containing flurbiprofen microsponges. Int. J. Pharm. v318, p103–117,

Farhan, J.A., Mohd, A.A., Zeenat, I.K., Roop, K.K. & Mushir, A. 2008 Development and in vitro evaluatiaon of an acid buffering bioadhesive vaginal gel for mixed vaginal infections. Acta Pharm. v58: p407-419,

El-Houssieny B., Hamouda H.M. 2010 .Formulation and evaluation of clotrimazole from pluronic F127 gels. Drug discovery and therapeutics; v4(1), p33-43

Roaa A. Nief, Ahmed A. Hussein, 2014 Preparation and Evaluation of Meloxicam Microsponges as Transdermal Delivery System Iraqi J Pharm Sc v23(2), p62-74

Zaki Rizkalla, C.M., Latif Aziz, R., Soliman, I.I., 2011. In-vitro and in vivo evaluation of hydroxyzine hydrochloride microsponges for topical delivery. AAPS Pharm. Sci. Technol. v12, p989–1001.

Costa P, Lobo J M S. Modeling and comparison of dissolution profiles. 2001 Europ J Pharm Sci. v13, p123-133.

Lee, J.-H Park T G and Choi H K. Development of oral drug delivery system using floating microspheres.1999 J. Microencapsul. v16 p715–729

Neha Gulati, Neha Tomar, Upendra Nagaich Miconazole Microsponges based topical delivery system for diaper dermatitis. 2016 Ars Pharm. v57(2): p77-87

Harish N. M, Prabhakara Prabhu, Subrahmanyam E. V. S. Formulation and evaluation of in situ gels containing clotrimazole for oral candidiasis. 2009 Indian J Pharm Sci v71(4) p 421–427



  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Indonesian J Pharm indexed by:


analytics View My Stats