Chemical composition of rhizome oleoresin and anti-inflammatory, antinociceptive and antipyretic activity of oleoresins of Alpinia allughas Roscoe. from tarai region of Uttarakhand

Ravendra Kumar, Sonali Sethi, Om Prakash, Anil Kumar Pant, Mahesh Kumar, Valery A. Isidorov, Lech Szczepaniak

Abstract


ABSTRACT

          The investigation of volatile constituents of the rhizome oleoresin of Alpinia allughas Roscoe. growing in tarai region of Kumaun hills, Uttarakhand, revealed the presence of 55 terpenoids. The major constituents identified in the rhizome oleoresin were α-eudesmol (21.3%), β-selinene (13.9%), valencene (9.6%), borneol (7.1%), α-humulene (5.3%) and 7-epi-α-selinene (5.2%). Other minor constituents identified were (E)-β-caryophyllene (3.8%), (6 E)-nerolidol (3.5%), (E,E)-farnesol (3.2%), caryophyllene oxide (2.5%), humulene oxide (2.7%), bornyl acetate (1.9%), coranarin- E (1.8%), linalool (1.8%) and α-terpineol (1.6%). The total identified constituents contribute 97.0% of the oleoresin. The rhizomes oleoresins exhibited significant antinociceptive activity with 34.79% inhibition at 50 mg/kg body weight and 43.24% at 100 mg/kg body wt. compare to standard drug ibuprofen (40 mg/kg body wt.), it also showed antipyretic activity in dose dependent manner with temperature reduction 77.57±5.88% at 50 mg/kg body wt. and 98.95±3.95% at 100 mg/kg body wt. after 3 hours. Oleoresin also showed 29.23% inhibition in carrageenin-induced paw edema at 50 mg/kg body wt. and 39.92% inhibition at 100mg/kg body wt. in compare to ibuprofen 40.06% at 40 mg/kg body weight.

Keywords Alpinia allughas Roscoe.; Zingiberaceae; α-eudesmol; β-selinene; anti-inflammatory; antinociceptive; antipyretic activity; oleoresins

 

 

 


References


REFRENCES

Adams RP., 2007. Identification of essential oil components by gas chromatography/mass Spectrometry, 4th Edition. Allured Business Media Publishing Corporation, Carol Stream, Illinois, USA.

Ali MS., Banskota AH., Tezuka Y., Saiki I., Kadota S. 2001. Antiproliferative activity of diarylheptanoids from the seeds of Alpinia blepharocalyx. Bio. Pharm. Bull. 24:525–528.

Almeida JRGdaS., Souza GR., Silva JC., Saraiva SRGdeL., Júnior RGdeO., Quintans JdeSS., Barreto, RdeSS., Bonjardim LR., Cavalcanti SCdeH., Junior LJQ. 2013. Borneol, a Bicyclic Monoterpene Alcohol, Reduces Nociceptive Behavior and Inflammatory Response in Mice. The Sci. Wor. J. 2013:1-5.

Arambewela LSR., Arawwawala LDAM., Ratnasooriya WD. 2004. Antinociceptive activities of aqueous and ethanolic extracts of Alpinia calcarata rhizomes in rats. J. Eth.pharm. 95:311–331.

Batista PA., Werner MFP., Oliveira EC., Burgos L., Pareira P., Brum LFS., Story GM., Santos ARS. 2010. The antinociceptive effect of (-)-linalool in models of chronic inflammatory and neuropathic hypersensitivity in mice. J. Pain. 11:1222.

Bendjeddou D., Lalaoui K., Satta D. 2003. Immunostimulating activity of the hot water-soluble polysaccharide extracts of Anacyclus pyrethrum, Alpinia galangal and Citrullus colocynthis. J. Eth. pharm.88:155–160.

Brown D. 1995. In: Kinderstey, D. (Ed.), the Royal Horticultural Society Encyclopedia of Herbs and their Uses. London. pp. 235–237.

Brzezinska-Slebodzinska E. 2001. Fever induced oxidative stress. The effect on thyroid status and the 5'-mono deiodinase activity, protective role of selenium vitamin. J. Phys. Pharm. 52:275-284.

Chirangini P., Sharma GJ., Sinba., Swapan K. 2004. Sulfur free radical reactivity with curcumin as reference for evaluating antioxidant properties of medicinal Zingiberales. J. Env.Path.Tox. Onc. 23(3):227-236.

Chao LK., Hua KF., Hsu HY., Cheng SS., Liu JY. Chang ST. 2005. Study of the anti-inflammatory activity of essential oil from leaves of Cinnamomum osmophloeum. J. Ag. Food Chem. 53:7274-7278.

de Lima AB., Santana MB., Cardoso AS., da Silva JKR., Maia JGS., Sousa PJCC. 2009. Antinociceptive activity of 1-nitro-2- phenylethane, the main component of Aniba canelilla essential oil. Phyt.med. 16:555-559.

Di Rosa M., Willoughby DA. 1971. Screens for anti-inflammatory drugs. J. Pharm. Pharm. 23:297-298.

George M., Pandalai KM. 1949. Investigation of plant antibiotics. Ind. J. Med. Res. 37: 169-181.

Fernandes ES., Passos GF., Medeiros R., da Cunha FM., Ferreira J., Campos MM., Pianowski LF., Calixto JB. 2007. Anti-inflammatory effects of compounds alpha-humulene and (-)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea. Eur. J. Pharm. 569:228-236.

Israf DA., Khaizurin TA., Syahida A., Lajis NH., Khozirah S. 2007. Cardamonin inhibits COX and iNOS expression via inhibition of p65NF-kappaB nuclear translocation and Ikappa-B phosphorylation in RAW 2647 macrophage cells. Mol. Immun. 44:673–679.

Kadota S., Tezuka Y., Prasain JK., Ali MS., Banskota, AH. 2003. Novel diarylheptanoids of Alpinia blepharocalyx. Cur. Top. Med. Chem. 3:203–225.

Kaleysa RR. 1975. Screening of indigenous plants for anthelmentic action against human Ascaris lumbricoides. Ind. J. Phys. Pharm. 19:47-49.

Kamatou GPP., Viljoen AM. 2010. A review of the application and pharmacological properties of α-bisabolol and α-bisabolol-rich oils. J. Am. Oil Chem. Soc. 87:1-7.

Kamatou GPP., van Zyl RL., van Vuuren SF., Viljoen AM., Figueiredo AC., Barroso JG., Pedro LG., Tilney PM. 2006. Chemical composition, leaf trichome types and biological activities of the essential oils of four related Salvia species indigenous to Southern Africa. J. Ess. Oil Res. 18:72-79.

Langerman L., Zakowski MI., Piskoun B., Grant GJ. 1995. Hot plate versus tail-flick: Evaluation of acute tolerance to continuous morphine infusion in rat model. J. Pharm. Tox. Meth.34:23-27.

Lathaa C., Shriram VD., Jahagirdar SS., Dhakephalkar PK., Rojatkara, SR. 2009. Antiplasmid activity of 1’-acetoxychavicol acetate from Alpinia galanga against multi-drug resistant bacteria. J. Eth.pharm. 123:522–525.

Leandro LM., Vargas FdeS., Barbosa PCS., Neves JKO., Silva JAda., Junior VFdaV. 2012. Chemistry and Biological Activities of Terpenoids from Copaiba (Copaifera spp.) Oleoresins. Molecule. 17.3866-3889.

Lee CC., Houghton P. 2005. Cytotoxicity of plants from Malaysia and Thailand used traditionally to treat cancer. J. Ethn. 100:237–243.

Lemmon RS., Sherman CL. 1964. Flowers of the World, Doubleday, New York.

Loe tschert W., Beese, G. 1983. Guia de las Plantas Tropicales, Ed. Omega, Barcelona.

Medeiros R., Passos GF., Vítor CE., Koepp J., Mazzuco TL., Pianowski LF., Campos MM., Calixto JB. 2007. Effect of two active compounds obtained from the essential oil of Cordia verbenacea on the acute inflammatory responses elicited by LPS in the rat paw. Brit. J. Pharmacol. 151:618-627.

Saini NK., Singhal M. 2012. Anti-inflammatory, analgesic and antipyretic activity of methanolic

Tecomaria capensis leaves extract. Asian Pac. J. Trop. Biomed. 2(11): 870-874

Oliveira Jr WM., Benedito RB., Pereira WB., Torres PA., Ramos CAF., Costa JP., Tomé AR., de Sousa DP., Freitas RM., Diniz MFFM., Almeida RN. 2013. Farnesol: antinociceptive effect and histopathological analysis of the striatum and hippocampus of mice. Fundam. Clin. Pharmacol. 27:419.

, OECD/OCDE. 2001. Acute oral toxicity-Acute toxic class method. Guideline for the testing of chemicals, guidance document on acute toxic class method.

Paula-Freire LIG., Andersen ML., Gama VS., Molska GR., Carlini ELA. 2014. The oral administration of trans-caryophyllene attenuates acute and chronic pain in mice. Phyt. Med. 21:356-362.

Pandey S., Prakash O., Zafar A., Hore SK., Pant AK., Mathela CS. 2007. Myorelaxant effect of essential oil of rhizome of Alpinia calcarata Rosc. on rat duodenal smooth muscle. Nat. Prod. Comm. 2(7):789-793.

Peana AT., Montis MG., Sechi S., Sircana G., D’Aquila PS., Pippia P. 2004. Effects of (-)-linalool in the acute hyperalgesia induced by carrageenan, L-glutamate and prostaglandin E2. Eur. J. Pharmacol. 497(3): 279-284.

Prakash, O., Joshi S., Pant AK., Chanotiya CS., Mathela CS. 2007. Volatile Constituents of Rhizomes and Leaves of Alpinia allughas Roscoe. J. Essen. Oil Res. 19(5): 407-409.

Purohit RM, Devi K. 1976. Chromatographic analysis of the essential oil from the rhizome of Alpinia allughas. Riechst Aromen, Koerperflegem. 26(7):139-142.

Pushpangadan P., Atal CK. 1984. Ethen medico botanical investigations in Kerela. J. Ethn. 111:59-77.

Rao RR., Babu RM., Rao, MRV., Babu, MGV. 1997. Studies on antipyretic, analgesic and hypoglycaemic activities of root of Gynandropsis gynandra Linn. Ind. Drug. 34(12):690- 694.

Ramachandran S., Rajini kanth B., Rajasekaran A., Manisenthil Kumar KT. 2011. Evaluation of anti-inflammatory and analgesic potential of methanol extracts of Tectona grandis flowers. Asian Pac. J. of Trop. Biomed. S155-S158.

Robinson JP., Balakrishnan V., Raj JS. 2009. Antimicrobial activity of Alpinia calcarata Rosc. and characterization of new α, β unsaturated carbonyl compounds. Adv. Bio. Res. 3(5-6):185-187.

Santos FA., Rao VS. 2000. Antiinflammatory and antinociceptive effects of 1,8-cineole a terpenoid oxide present in many plant essential oils. Phyto. Res. 14(4):240-244.

Seibert K., Zhang Y., Leahy K., Hauser S., Masferrer J., Perkins W. 1994. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc. Nat. Acad. Sci. 91:12013-12017.

Selye H. Further studies concerning participation of the adrenal cortex in the pathogenesis of the arthritis. Brit. Med. Jour. 1949; 2:1129-1135.

Shi GF., An LJ., Jiang., Guan S., Bao YM. 2006. Alpinia protocatechuic acid protects against oxidative damage in vitro and reduces oxidative stress in vivo. Neur. Lett. 403:206–210.

Smith JB., Willis AL. 1971. Aspirin selectivity inhibition prostaglandin production in human platelets. Nat. New Bio. 231:235-239.

Sethi S., Prakash O., Pant AK. 2015. Essential oil composition, antioxidant assay and antifungal activity of essential oil and various extracts of Alpinia allughas (Retz.) Roscoe leaves. Cogent Chem. 1:1079349.

Subramanian K., Selvakkumar C., Vinaykumar KS., Goswami N., Meenakshisundaram S., Balakrishnan, A. 2009. Tackling multiple antibiotic resistances in enteropathogenic Escherichia coli (EPEC) clinical isolates: a diarylheptanoid from Alpinia officinarum shows promising antibacterial and immunomodulatory activity against EPEC and its lipopolysaccharide-induced inflammation. Int. J. Anti. Agen. 33:244–250.

Syamsir DRB. 2009. Essential oils and biological activities of three selected wild Alpinia species. Master thesis, Institute of Biological Sciences, Faculty of Sciences, University of Malaya, Kuala Lumpur, Malaysia.

Vankar PS., Vandana T., Singh LW., Ningombam S. 2006. Antioxidant properties of some exclusive species of Zingiberaceae family of Manipur. Elec. J. Env. Ag. Food Chem. 5(2):1318-1322.

Vinegar R., Schreiber W., Hugo R. 1969. Biphasic development of carrageenan edema in rats. J. Pharm. Exp. Therap. 166(1):96-103.

Vogel HG., Scholkens BA., Sandow J., Muller G., Vogel WH. 2007. Drug discovery and evaluation. Berlin Heidelberg: Springer-Verlag;

Winter CA., Risley EA., Nuss GW. 1962. Carrageenan-induced edema in hind paws of the rats as an assay for antiinflammatory drugs. Proc. Soc. Exp. Bio. Med. 111:544-547.

Yoon WJ., Kim SS., Oh TH., Lee NH., Hyun CG. 2009. Cryptomeria japonica essential oil inhibits the growth of drug-resistant skin pathogens and LPS-induced NO and pro-inflammatory cytokine production. Polish J. Microbiol. 58:61-68.




DOI: http://dx.doi.org/10.14499/indonesianjpharm28iss3pp%25p

Refbacks

  • There are currently no refbacks.




Copyright (c) 2017 INDONESIAN JOURNAL OF PHARMACY

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Indonesian J Pharm indexed by:

                                               

web
analytics View My Stats