DESIGN AND DEVELOPMENT OF ORAL SUSTAINED IN SITU GELLING SYSTEM OF ROXATIDINE
Gel dosage forms are successfully used as drug delivery systems to control drug release and protect the medicaments from a hostile environment. The main objective of this present work is to formulate and evaluate in situ gels of roxatidine for the treatment of peptic ulcer. This system utilizes polymers that exhibit sol-to-gel phase transition due to change in specific physico-chemical parameters. In the present work in situ gels have been developed by using gellan gum and sodium alginate based on the concept of ion activated systems. Sol-to-gel transformation occurred in the presence of monovalent/divalent cations. Formulations were evaluated for clarity, drug content, in vitro gelling capacity, determination of pH, in situ release study, viscosity, gel strength, ex vivo gelation and stability study. All the results found to be satisfactory. Experimental part showed that viscosity of sols and gel strength was increased with increase in the concentration of polymers, also drug release gets sustaining. The formulations were therapeutically efficacious, sterile and provided sustained release of the drug over a period of time. These results demonstrated that the developed system is an alternative to conventional drug delivery systems and can improve patient compliance.
Key words: In situ gels, Roxatidine, Peptic ulcer.
Patel NA, Mahesh KS, Ravi K, Senthil A, Viral G P (2012). Development and evaluation of oral gastro-retentive in situ gel of famotidine. Indo-Global Res J Pharm Sci. 2(1):238-43.
Aman K, Suchetha R, Shankraiah.M.M. Venkatesh.J.S, Nagesh.C (2011). In Situ Gelling System - An Overview.Pharmacologyonline.2:28-44.
Tripathi KD (2003). Drugs for peptic ulcer in essentials of medical pharmacology. 5th edn. New Delhi: Jaypee Brothers Medical Publishers. 585-91.
Debjit B, Chiranjib, Tripathi KK, Pankaj, Sampath KP (2010). Recent treands of treatment and medication peptic ulcerative disorder.Int J Pharm Tech Res. 2(1):970-80.
Harish NM, Prabhu P, Charyulu RN, Gulzar MA, Subrahmanyam EVS (2009). Formulation and evaluation of in situ gels containing clotrimazole for oral candidiasis. Int J Pharm Sci.10(8):421-27.
Hetangi R, Patel V, Moin M (2011). In situ gel: development, evaluation and optimization using 32 factorial design. J Pharm Sci Res.3(4):1156-62.
Hareesh BK, Gulzar MA, Narayana CR (2012). Development and evaluation of in situ gels of Moxifloxacin for the treatment of Periodontitis. Indonesian J Pharm. 23(3):141-146.
Nirmal HB, Bakliwal SR, Pawar SP (2010). In situ gel: New trends in controlled and sustained drug delivery system. Int J Pharm Tech Res. 2(2):1398-408.
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