FORMULATION AND EVALUATION OF ORAL SUSTAINED IN SITU GELLING SYSTEM OF ROXATIDINE

Mohammed Gulzar Ahmed, Chirag Kapoor, Sanjana A

Abstract


Gel dosage forms are successfully used as drug delivery systems to control drug release and protect the medicaments from a hostile environment. The main objective of this present work is to formulate and evaluate in situ gels of roxatidine for the treatment of peptic ulcer. This system utilizes polymers that exhibit sol-to-gel phase transition due to change in specific physico-chemical parameters. In the present work in situ gels have been developed by using gellan gum and sodium alginate based on the concept of ion activated systems. Sol-to-gel transformation occurred in the presence of monovalent/divalent cations. Formulations were evaluated for clarity, drug content, in vitro gelling capacity, determination of pH, in situ release study, viscosity, gel strength, ex vivo gelation and stability study. All the results found to be satisfactory. Experimental part showed that viscosity of sols and gel strength was increased with increase in the concentration of polymers, also drug release gets sustaining. The formulations were therapeutically efficacious, sterile and provided sustained release of the drug over a period of time. These results demonstrated that the developed system is an alternative to conventional drug delivery systems and can improve patient compliance.

Key words: In situ gels, Roxatidine, Peptic ulcer.


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References


Divyesh HS., Hitesh DD., Pragna S., Alkesh KB., 2016. Formulation development and evaluation of a gastroretentive In situ oral gel of cefuroxime axetil. J Yun Pharm .8(4):324-329.

Hareesh BK., Gulzar MA., Narayana CR., 2012. Development and evaluation of in situ gels of Moxifloxacin for the treatment of Periodontitis. Indonesian J Pharm. 23(3):141-146.

Harish NM., Prabhu P., Charyulu RN., Gulzar MA., Subrahmanyam EVS., 2009. Formulation and evaluation of in situ gels containing clotrimazole for oral candidiasis. Int J Pharm Sci.10(8):421-27.

http://home.intekom.com/pharm/hmr/roxit.html

Pallavi C., Pratibha., Gnanrajan G., Preethi K., 2016. In situ gel: A review. Ind J Pharm Biol Res. 4(2): 11-19

Patel NA., Mahesh KS., Ravi K., Senthil A., Viral GP., 2012. Development and evaluation of oral gastro-retentive in situ gel of famotidine. Indo-Global Res J Pharm Sci. 2(1):238-43.

Ramana BV., Jalalu SS., Swapna C., et al., 2016. Design and development of floating in situ gel of pantoprazole. Scholar Res Lib. 8(8): 239-249.

Roshan RM., Vaishali G., Gupta S., 2015. Novel study in sustained release drug delivery system: A Review. Int J Pharm Med Res. 3(2): 204-215.

Tripathi KD., 2013. Drugs for peptic ulcer in essentials of medical pharmacology.7th edn. New Delhi: Jaypee Brothers Medical Publishers. 585-91.




DOI: http://dx.doi.org/10.14499/indonesianjpharm28iss3pp178

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