QUALITY OF LIFE ANALYSIS IN DIABETES MELLITUS TYPE 2 PATIENTS USING MONOTHERAPY AND COMBINATION TREATMENT OF MEDICINE
Treatment of diabetes mellitus patients can be vary, using monotherapy or combination therapy, and it depends on the severity of the disease from each person. That variation will give influences to the patient’s clinical condition and also their quality of life. The objective of this study is to determine the average of quality of life’s score in diabetes mellitus patients who use monotherapy and combination therapy of antidiabetic oral in Public Health Center of Kotagede 1 Yogyakarta.
This study was conducted in a cross sectional study. Subjects were people who had an age above 18 years old, got the diagnose of diabetes mellitus type 2 and have been attended to the public health center, and also consumed of oral antidiabetic monotherapy or combination. The measurement of quality of life is using a DQLCTQ questionnaire in Bahasa Indonesia version. Analysis statistic with independent sample T-test was used to determine the differences between quality of life in patients who use monotherapy and combination therapy.
Subjects who met the inclusion criteria are 52 patients. About 82.70% (43 patients) of the patients used oral antidiabetic combination and the other (9 patients) used oral antidiabetic monotherapy. The average of quality of life in monotherapy patients (78.95 + 11.36) was higher than in combination therapy patients (75.18 + 10.57). Result of the analysis statistic showed that there is no significant differences (p 0.095) of quality of life between monotherapy patients and combination therapy patients.
Bonomi AE., Patrick DL., Bushnell DM., Martin M, 2000, Validation of the United States’ version of the World Health Organization Quality of Life (WHOQOL) instrument, Journal of Clinical Epidemiology 53 : 19-23.
Garratt AM., Schmidt L., Fitzpatrick R., 2002, Patient-assessed health outcome measures for diabetes : a structured review, Diabetes Medicine 19; 1-11.
International Diabetes Federation, 2013 , IDF Diabetes Atlas Sixth Edition, www.idf.org/diabetesatlas.
International Diabetes Federation, 2015, Diabetes in Indonesia, http://www.idf.org/membership/wp/indonesia.
Inzucchi SE., Bergenstal RM., Buse JB., Diamant M., Ferrannini E., Nauck M., Peters AL., Tsapas A., Wender R., and Matthews DR., 2015, Management of Hyperglycemia in Type 2 Diabetes, 2015 : A Patient-Centered Approach. Update to a Position Statement of the American Diabetes Association and the European Association for the Study of Diabetes, Diabetes Care 2015 ;38: 140-149.
Lau CY., Qureshi AK., Scott SG., 2004, Association between glycaemic control and quality of life in diabetes mellitus, J Postgrad Med 50 : 189-94.
MyersVH., McVay MA., Brashear MM., Johannsen NM., Swift DL., Kramer K., Harris MN., Johnson WD., Earnest CP., Church TS., 2013, Exercise Training and Quality of Life in Individuals with Type 2 Diabetes, Diabetes Care 36 : 1884-1890.
Nagpal J., Kumar A., Kakar S., Bhartia A., 2010, The Development of ‘Quality of Life Instrument for Indian Diabetes Patients (QOLID) : A Validation and Reliability Study in Middle and Higher Income Groups, JAPI 58 : 295-304.
Raptis SA., Hatziagelaki E., Dimitriadis G., Draeger KE., Pfeiffer C., Raptis AE., 1999, Comparative Effect of Glimepiride and Glibenclamide on Blood Glucose, C-peptide and insulin concentrations in the fasting and postprandial state in normal man, Experimental and Clinical Endocrinology & Diabetes 107 (1999):350-355.
Sari RM., Thobari JA., Andayani TM., 2011, Evaluation Quality of Life of Type 2 Diabetic Patients With Oral Antidiabetic Therapy at Ambulatory Clinic in RSUP Dr. Sardjito, Jurnal Manajemen dan Pelayanan Farmasi Vol.1 No.1 : 35-42.
Sharma T., Kalra J., Dhasmana DC., Basera H., 2014, Poor Adherence to Treatment : A major challenge in diabetes, Journal Indian Academy of Clinical Medicine 15 (1) : 26-9.
Shen W., Kotsanos JG., Huster WJ., Mathias SD., Andrejasich CM., and Patrick DL., 1999, Development and Validation of the Diabetes Quality of Life Clinical Trial Questionnaire, Med Care, 1999 Apr;37 (4Suppl Lilly):AS45-66.
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