Antiinflamatory and antidepressive activities of Extract Curcuma xanthorrhiza Roxb in Systemic Lupus Erythematosus

Maria Caecilia Setiawati, Zulies Ikawati, I Nyoman Kertia

Abstract


Systemic Lupus Erythemathosus  is an autoimmune, inflammatory, chronic disorder characterized by multiorgan system involvement. Depression and anxiety are frequent complaints among patients with lupus erythematosus, so antidepressive treatment should be an important element of the therapy of patients with lupus erythematosus. Research into curcumin’s potential as a treatment for depression is still in its infancy, although several potential antidepressant mechanisms of action have been identified. 4-weeks double-blind, placebo-controlled clinical trial was conducted in 14 SLE patients (10 as treatment group and 4 as control group) The BDI (Beck Depression Inventory) score was calculated and TNF α concentration was measured in the serum subjects before and after treatment. Correlation between TNF α concentration and BDI was assessed. After 4 weeks treatment, the TNF α concentration from subjects in treatment group were significantly lower than before ( p <0.001)  but the BDI score were not significantly lower than before (p = 0.059).  The TNF α concentration and BDI score showed positive correlation, p = 0,024. This  study demonstrate that  Curcuma xanthorrhiza Roxb extract can decrease serum TNF α concentration and  reduce clinically symptoms of depression in SLE patients 


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References


Aggarwal B, Potential Therapeutic Effects of Curcumin, the Anti-inflammatory Agent, Against Neurodegenerative, Cardiovascular, Pulmonary, Metabolic, Autoimmune and Neoplastic Diseases, Int J Biochem Cell Biol, 2009; 41(1): 40-50

Bergman, Joseph MD*; Miodownik, Chanoch MD†; Bersudsky, Yuly MD, PhD†; Sokolik, Shmuel‡; Lerner, Paul P.§; Kreinin, Anatoly MD, PhD*; Polakiewicz, Jacob MD*; Lerner, Vladimir MD, PhD† , Curcumin as an Add-On to Antidepressive Treatment: A Randomized, Double-Blind, Placebo-Controlled, Pilot Clinical Study, 2013,Clin Neuropharm vol 36, issue 3, p 73-77

Chen J, Song Y, Yang J, Zhang Y, Zhao P, Zhu XJ, et al. The contribution of TNF-α in the amygdala to anxiety in mice with persistent inflammatory pain. Neurosci Lett. 2013;541:275–80.

Jagetia GC, Aggarwal BB. “Spicing up” of the immune system by curcumin. J. of Clin Immunol. 2007;27(1):19–35.

Jarpa E, Babul M, Calderón J, González M, Martínez ME, Bravo-Zehnder M, et al.Common mental disorders and psychological distress in systemic lupus

erythematosus are not associated with disease activity. Lupus. 2011;20:58–66.

Jurenka JS, Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev. 2009 Jun;14(2):141-53.

Krishnadas R, Cavanagh J. Depression: an inflammatory illness? J Neurol Neurosurg Psychiatry,. 2012;83:495–502.

Kulkarni SK, Dhir A, Akula KK. 2009, Potentials of curcumin as an antidepressant. Sci World J 2009;9:1233-1241 https://www.ncbi.nlm.nih.gov/pubmed/19882093

Lopresti AL, Hood SD, Drummond PD. Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects. J Psychopharmacol. 2012;26(12):1512–1524

Postal, Mariana, Lapa, Aline T., Sinicato, Nailu A., Pelicari, Karina, Costallat, Lilian, Appenzeller, Simone, Tumor Necrosis Factor Alpha Is Associated With Mood Disorders In Patients With Systemic Lupus Erythematosus., Arthritis & Rheumatism, Volume 64, 2012

Snowdon J, 2001, Prevalence of depression in old age , The British J. of Psychiatry May 2001, 178 (5) 476-477; DOI: 10.1192/bjp.178.5.476 http://bjp.rcpsych.org/content/178/5/476

Zhang, L., Xu T,Wang S, Yu L, Liu D, Zhan R, et al, Curcumin produces antidepressant effects via activating MAPK/ERK-dependent brain-derived neurotrophic factor expression in the amygdala of mice, Behav Brain Res 235, Issue 1, 1 November 2012, Pages 67–72, http://dx.doi.org/10.1016/j.bbr.2012.07.019

Zorrilla EP, Luborsky L, McKay JR, Rosenthal R, Houldin A, Tax A, et al. The relationship of depression and stressors to immunological assays: a metaanalytic review. Brain Behav Immun. 2001;15:199–226.




DOI: http://dx.doi.org/10.14499/indonesianjpharm28iss3pp185

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